Uric Acid Nephrolithiasis in Gout

Predisposing Factors

  1. TS'AI-FAN YÜ, M.D.; and
  2. ALEXANDER B. GUTMAN, M.D., F.A.C.P.
  1. Requests for reprints should be addressed to Alexander B. Gutman, M.D., Director of Medicine, The Mount Sinai Hospital,
    11 E. 100th St., New York, N. Y. 10029
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Excerpt

It has been known since the time of Galen that the gouty are singularly subject to stone; indeed, the prevalence of uric acid urolithiasis among the gouty is of an order 1,000 times greater than in the nongouty, occurring in 10 to 20% of cases of primary gout in the United States (1) as compared to an estimated incidence of about 0.01% in the population of the country as a whole.* In our own experience, which to be sure is somewhat weighted by inclusion of a number of cases referred specifically for medical management of stone, 280 of 1,258 patients

Article and Author Information

  • From the Department of Medicine, The Mount Sinai Hospital, New York, N. Y.

  • This work was supported in part by grant-in-aid A-162, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Md.

  • ↵* This estimate is based on the results of a survey by Boyce, Garvey, and Strawcutter (2) who found that among admissions to general hospitals in the United States the diagnosis of urinary calculus was made in 9.47 persons per 10,000 population. The general experience in this country is that uric acid calculi constitute 5 to 10% of all renal stones in adults (Table 12 by Atsmon, de Vries, and Frank (2)), although in some series (3, 4) it was 17%.

    • Received June 7, 1967.
    • Accepted August 8, 1967.
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  1. Ann Intern Med December 1, 1967 vol. 67 no. 6 1133-1148
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