Role of Lupus Erythematosus Factor and Accessory Serum Factors in Production of Extracellular Nuclear Material

  1. HARVEY E. GOLDEN, M.D.; and
  2. FREDERIC C. MCDUFFIE, M.D., F.A.C.P.
    Rochester, Minnesota
  1. Requests for reprints should be addressed to Frederic C. McDuffie, M.D., Mayo Clinic,
    Rochester, Minn. 55901
    .

Excerpt

Since the original description of the lupus erythematosus (LE) cell by Hargraves, Richmond, and Morton (1), it has become clear that this inclusion-containing cell is formed in two stages (2, 3). In the first stage an abnormal gamma G globulin, the LE factor, reacts with a component of the nucleus, apparently the deoxyribonucleic acid-histone complex (4), to form nuclear material that is altered in appearance. This altered nuclear material may then be phagocytized in the second stage to form LE cells, or it may remain extracellular. This altered extracellular nuclear material (ECM) (5) takes several forms, the most commonly recognized

This 100-word excerpt has been provided in the absence of an abstract.

Article and Author Information

  • From the Section of Microbiology, Mayo Clinic and Mayo Foundation, and the Mayo Graduate School of Medicine (University of Minnesota), Rochester, Minn.

  • This investigation was supported in part by training grant AM-5492, National Institutes of Health, Bethesda, Md.

  • This paper was read at the meeting of the American Rheumatism Association, Denver, Colo., June 18, 1966.

    • Received April 6, 1967.
    • Accepted May 31, 1967.
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  1. Ann Intern Med October 1, 1967 vol. 67 no. 4 780-790
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