Metabolic Effects of Intracellular Infections in Man

Excerpt

During the past 2 decades extraordinary advances have occurred in our understanding of the biology of normal cells. Dramatic progress has been made in defining the "molecular pathology" of diverse diseases; in particular, the molecular consequences of infection have been characterized extensively in bacterial and cultured mammalian cells infected by viruses. Much less is known, however, of the more complicated biochemical and metabolic events during infection of intact mammalian hosts. Studies in both experimental animals and man are limited in number. The human studies were conducted mainly during the preantibiotic era, and investigations generally were initiated only after illness was