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Immunologic Memory of the Normal and the Leukemic Lymphocyte
- JEROME I. BRODY, M.D., F.A.C.P.; and
- FRANK OSKI, M.D.
- Requests for reprints should be addressed to Jerome I. Brody, M.D., Department of Medicine, Graduate Hospital of the University of Pennsylvania, Philadelphia, Pa. 19146.
Excerpt
The purpose of this study was to determine whether the immune indolence of the leukemic lymphocyte is complete or whether its failure to respond to stimuli is selective and depends upon the nature of the antigen to which the lymphocyte's host organism is exposed. Although the diminished in vivo and in vitro responses of the neoplastic lymphocyte to immunogenic and metabolic stimulants are acknowledged, the limits of this hyporeactivity and the extent of lymphocytic immunologic recall remain undefined. There is no established experimental evidence to support the concept that the leukemic lymphocyte's failure to synthesize in vivo antibody to one
Acknowledgment
The authors thank Drs. Lawrence H. Beizer and Noel Rowan for referring their patients to us for study.
Article and Author Information
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From the Department of Medicine, the Graduate Hospital of the University of Pennsylvania, the Department of Pediatrics, the Hospital of the University of Pennsylvania, and the University of Pennsylvania School of Medicine, Philadelphia, Pa.
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This study was supported by research grants CA-07000-05 and HE-01919 and training grant 5 T1 CA-5159-03, U. S. Public Health Service, Washington, D. C.
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Dr. Brody is the recipient of career development ward 1-K3-CA 8371, U. S. Public Health Service.
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- Received March 27, 1967.
- Accepted June 1, 1967.
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