RSS Feeds
Pulmonary Arterial Occlusion and Surfactant Production in Humans
- ALTON I. SUTNICK, M.D., F.A.C.P.; and
- Louis A. SOLOFF, M.D., F.A.C.P.
- Requests for reprints should be addressed to Alton I. Sutnick, M.D., Research Physician, Institute for Cancer Research, 7701 Burholme Ave., Philadelphia, Pa. 19111.
Excerpt
Local congestive atelectasis is a common occurrence with pulmonary infarction (1); its pathogenesis, however, is unclear. A prime role has been assigned to ischemic anoxia and subsequent reactive hyperemia from collateral bronchial arterial flow (2-5). The demonstration that pulmonary surfactant is secreted by alveolar epithelial cells (6) has raised the possibility that the altered metabolism of these cells may also be a factor. The purpose of this report is to examine the surface activity in extracts of human lungs involved with emboli and to attempt to relate these findings to the pathologic anatomic changes in the lung.
Acknowledgments
The authors are indebted to the Departments of Pathology and Physiology of Temple University School of Medicine for their enthusiastic cooperation and to Shirley Berk for technical assistance.
Article and Author Information
-
From the Institute for Cancer Research, Fox Chase, and the Temple University School of Medicine, Philadelphia, Pa.
-
This study was supported in part by grants CA-06551 and HE-08595, U. S. Public Health Service, Washington, D. C., and by the Pennsylvania Tuberculosis and Health Society, Philadelphia, Pa.
-
- Received March 20, 1967.
- Accepted May 26, 1967.
Related Clinical Content
