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A Spectrum of Myopathy Associated with Alcoholism
II. Light and Electron Microscopic Observations
- GEORGE KLINKERFUSS, M.D.;
- VIRGIL BLEISCH, M.D.;
- MARCONI M. DIOSO, M.D.; and
- GERALD T. PERKOFF, M.D., F.A.C.P.
- Requests for reprints should be addressed to Gerald T. Perkoff, M.D., St. Louis City Hospital, 1515 Lafayette Ave., St. Louis, Mo. 63104.
Excerpt
The occurrence of several types of acute muscular abnormalities in chronic alcoholism, first reported by Hed, Larson, and Wahlgren (1), now is well-known (2-6). Ekbom, Hed, Kirstein, and Astrom (3) and Serratrice, Toga, and Roux (4) have described the clinical and histologic features of a more chronic myopathy in patients with severe alcoholism. However, with the exception of extensive studies of a single patient reported by Douglas, Fewings, Casley-Smith, and West (6), information concerning the ultrastructural features of the skeletal muscle abnormalities associated with alcoholism is lacking.
In the preceding paper (7) we described the clinical and laboratory abnormalities found
Article and Author Information
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From the Departments of Neurology, Medicine, and Pathology, Washington University School of Medicine, and the Washington University Medical Service and the Snodgrass Laboratory, St. Louis City Hospital (Max S. Starkloff Division), St. Louis, Mo.
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These studies were supported by research grants AM 08377, AM 15062, NB 04513, 5-SO-1 FR 538905, and FR-36, the U. S. Public Health Service, Washington, D. C., and by grants from the Beaumont May Institute of Neurology and from the Institute of Medical Education and Research of the City of St. Louis, Mo.
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- Received April 10, 1967.
- Accepted April 12, 1967.
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