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The Prognostic Significance of Chromosome Abnormalities in Colon Tumors
- HERBERT A. LUBS, M.D.; and
- STUART KOTLER, M.D.
- Requests for reprints should be addressed to Herbert A. Lubs, M.D., Yale University School of Medicine, Department of Medicine, 333 Cedar St., New Haven, Conn. 06510.
Excerpt
The chromosome complements of all well-studied human solid tumors have been abnormal. Similar tumors have been shown to have widely different types of chromosome abnormalities. This variation suggests that many tumors could be subgrouped by the type of cytogenetic abnormality present as well as by the presence or absence of specific marker chromosomes. Until recently, the number of adequately studied tumors of a given type has been too small to permit possible correlation of these subgroups with various clinical parameters such as the tendency to metastasize, response to therapy, or longevity. Two studies have recently been reported in which a
Article and Author Information
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From the Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn.
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This study was supported in part by career development award K3-CA-19, 745, the National Cancer Institute, National Institutes of Health, Bethesda, Md., by research grant GM 11078-03, the General Medical Science Branch, U. S. Public Health Service, Washington, D. C., and by the John A. Hartford Foundation, Inc., New York, N. Y.
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- Received March 1, 1967.
- Accepted April 11, 1967.
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