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Studies of Monoclonal Immunoglobulins (M-Components) in Various Kindreds
- RALPH C. WILLIAMS, JR., M.D.;
- JEFFREY L. ERICKSON, B.A.;
- HERBERT F. POLESKY, M.D.; and
- WILLIAM R. SWAIM, M.D.
- Requests for reprints should be addressed to Ralph C. Williams, Jr., M.D., Box 91, University Hospitals, Minneapolis, Minn. 55455.
Excerpt
The occurrence of electrophoretically sharp, homogeneous serum proteins related to one of the immunoglobulin classes γG, γA, or γM (1) has generally been connected in the minds of clinicians with the distinct entities of multiple myeloma or Waldenström's macroglobulinemia. That such unique sharply defined proteins, termed M-components (2-4), are products of a presumably uniform or monoclonal cell population has been the concept generally held (5). It is also apparent that M-components may occur in association with diverse pathologic states, many neoplastic but others not directly associated with a malignant process (3, 5-11). In some instances M-components have been described in
Acknowledgments
We are indebted to Drs. William D. Terry and Henry G. Kunkel for H-chain typing of isolated M-components and to Miss Marsha Olesen and Mrs. M. F. Weinhold for contacting the relatives involved in this study. Miss Jean Emmons and Mrs. Donna Ripley contributed invaluable technical assistance, and Dr. Eugene Johnson provided extremely helpful statistical advice.
Article and Author Information
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From the Department of Medicine, University Hospitals, War Memorial Blood Bank, and Minneapolis Veterans Administration Hospital, Minneapolis, Minn.
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This study was supported by grant 5 T1 AM 5461-03, U. S. Public Health Service, Washington, D. C., and by a grant from the Minnesota Arthritis Foundation, Minneapolis, Minn.
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- Received February 27, 1967.
- Accepted April 7, 1967.
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