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Precipitous Fall in Serum Calcium, Hypotension, and Acute Renal Failure After Intravenous Phosphate Therapy for Hypercalcemia
Report of Two Cases
- STANLEY SHACKNEY, M.D.; and
- JACK HASSON, M.D.
- Requests for reprints should be addressed to Stanley Shackney, M.D., National Cancer Institute, Wiscon Bldg., Room 3C12, National Institutes of Health, Bethesda, Md. 20014.
Excerpt
In a search for more effective forms of therapy for hypercalcemia, Goldsmith and Ingbar (1) have recently focused on the use of oral or parenteral phosphate. They reported a series of 20 hypercalcemic patients in whom phosphate safely lowered the serum calcium. Subsequently, two additional patients were reported in whom transient hypocalcemia was observed after intravenous phosphate infusion; caution with this form of therapy was advised (2).
We wish to extend this note of caution further, in view of the precipitous decrease in serum calcium associated with hypotension and acute renal failure after therapy with intravenously administered phosphate buffer in
Summario in Interlingua
Es presentate le casos de duo patientes hypercalciemic tractate con intravenose tampon phosphatic. In ambe casos, declinos precipitose del nivellos seral de calcium esseva observate. Ambe patientes disveloppava hypotension e acute insufficientia renal. In un del duo, bilateral necrosis del cortice renal se disveloppava. Es commentate le mechanismos possibile, le interrelationes, e certe consequentias ab le puncto de vista del therapia.
Article and Author Information
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From the Departments of Medicine and Pathology, The Jewish Hospital of St. Louis and Washington University School of Medicine, St. Louis, Mo.
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- Received October 24, 1966.
- Accepted December 19, 1966.
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