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Clinical Alcohol Hypoglycemia
- M. CARNEIRO DEMOURA, M.D.;
- J. PINTO CORREIA, M.D.; and
- F. MADEIRA, M.D.
- Requests for reprints should be addressed to M. Carneiro deMoura, M.D., Department of Patologia Médica, Hospital of Santa Maria, Medical School of Lisbon, Lisbon-4, Portugal.
Excerpt
Brown and Harvey (1) in 1941 were the first to report hypoglycemia in chronic alcoholics that was precipitated by the ingestion of alcoholic beverages. Although the hypoglycemia was initially attributed to ingredients other than ethanol, it was subsequently shown that ethanol per se can produce hypoglycemia (2, 3). Since then other authors have confirmed the existence of alcohol hypoglycemia, and data have been presented recently that help to elucidate the pathways of its production (3-5). During the past 4 years we have been able to study three additional cases of clinical alcohol hypoglycemia with documented episodes of hypoglycemia and minimal
Acknowledgments
The authors are indebted to Norbert Freinkel, M.D., Kettering Professor of Medicine, Northwestern University, Chicago, for his advice and critical review of the manuscript. They also wish to thank Dr. Fernando Barros, Chief, Biochemistry Laboratory, Santa Maria Hospital, for his cooperation and Drs. Armando Bastos and Pedro Lisboa, Assistants, Department of Patologia Médica, for permission to publish data on Cases 2 and 3. We also thank Sisters Maria Luísa and Lidia for their help in the investigation and Miss Isaura Benido for secretarial assistance.
Summario in Interlingua
Es describite le casos de tres patientes con clinic hypoglycemia de alcoholicos. Le divergentias notate in le historias clinic esseva supportate per investigationes laboratorial. Un significative responsa hypoglycemic esseva evocate in duo del patientes per standardisate infusiones de alcohol, sed in le tertie del patientes iste phenomeno non poteva esser reproducite. Un intensificate susceptibilitate pro le effectos hypoglycemic de alcohol esseva confirmate in un del subjectos per medio de un test a ethanol e tolbutamida. Le datos indica que il existe nulle unificante configuration del metabolismo de hydra to de carbon in patientes con clinic hypoglycemia de alcoholicos. Le condition representa un syndrome in le qual, probabilissimemente, differente defectos metabolic es interessate.
Article and Author Information
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From the Department of Patologia Médica, University Hospital of Santa Maria, Lisbon Medical School, Lisbon, Portugal.
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- Received September 30, 1966.
- Accepted January 30, 1967.
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