Use of Medium Chain Triglycerides in Malabsorption
- NORTON J. GREENBERGER, M.D.;
- RICHARD D. RUPPERT, M.D.; and
- MANUEL TZAGOURNIS, M.D.
- Requests for reprints should be addressed to Norton J. Greenberger, M.D., Department of Medicine, Ohio State University Hospital, 410 W. 10th Ave., Columbus, Ohio 43210.
Excerpt
Recent clinical observations have indicated that triglycerides containing medium chain fatty acids may be useful in decreasing the steatorrhea associated with a variety of malabsorptive disorders. It has been demonstrated that medium chain triglycerides (MCT) are of value in treating patients with pancreatic insufficiency (1), extrahepatic biliary tract obstruction (2), postgastrectomy steatorrhea (3), a-beta-lipoproteinemia (4), intestinal lymphangiectasia (5), cystic fibrosis of the pancreas (6), and massive small-bowel resection (7). Although it has been well documented that therapy with MCT results in decreased steatorrhea, there is little evidence available correlating decreased steatorrhea with weight gain. Moreover, there is little information concerned
This 100-word excerpt has been provided in the absence of an abstract.
Acknowledgment
We are indebted to Mr. Gerard S. Knight of the Drew Chemical Corp., Boonton, N. J., and to Dr. Herbert P. Sarett of Mead Johnson & Co., Evansville, Ind., for generous supplies of medium chain triglyceride oil and powdered formula diet (product 7010-H), respectively. We thank Mrs. Kay Mitchell, dietician, for her assistance in this study.
Summario in Interlingua
Le uso de triglyceridas continente acidos grasse a catenas intermedie esseva investigate in un gruppo de 12 patientes con malabsorption. Therapia a triglyceridas a catenas intermedie resultava in un declino significative de steatorrhea in 9 del patientes, e in 6 de istes un minime sed nette ganio de peso esseva notate. Diarrhea de grado sever e invalidante esseva meliorate in 6 del casos. Le melioration le plus frappante esseva observate in 5 patientes con enteritis regional, durante que minus marcate grados de melioration esseva obtenite in patientes con scleroderma, carcinoma del pancreas, insufficientia pancreatic, e cirrhosis de Laennec. Duo patientes manifestava pejoration del diarrhea e dolores abdominal durante le curso del therapia. Nulle significative alteration esseva notate in le nivellos de glucosa sanguinee, de nonesterificate acidos grasse del plasma, e de insulina seral in 10 subjectos normal post le ingestion de 30 ml de oleo a triglycerida a catenas intermedie. Es concludite que le therapia sub discussion es possibilemente un adjuncto nutritional de valor in patientes con malabsorption.
Article and Author Information
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From the Division of Gastroenterology, Department of Medicine, Ohio State University College of Medicine, Columbus, Ohio.
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This study was supported in part by grant FR-34, U. S. Public Health Service, Washington, D. C.
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- Received October 31, 1966.
- Accepted December 12, 1966.
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