Immunotherapy of Pseudomonas Infections
- KEHL MARKLEY, M.D.
- Laboratory of Biochemical Pharmacology
National Institute of Arthritis and Metabolic Diseases
National Institutes of Health
Bethesda, Md.
Excerpt
An increasingly serious problem for the past decade or more has been the rising prevalence of infections due to Pseudomonas aeruginosa. Pseudomonas bacteremia occurs in elderly, debilitated, and chronically ill patients, in premature infants, in patients treated with ionizing radiation, and in patients suffering from thermal burns. In leukemic and burned patients pseudomonas septicemia is the terminal cause of the majority of deaths.
Therapy has been directed [1] toward treatment of the infection after Pseudomonas has been isolated from the blood stream or other tissues or [2] toward prophylaxis in those conditions that predispose to pseudomonas infections. Antibiotics such as
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