Chronic Active Hepatitis Treated with 6-Mercaptopurine—Sustained Remission
- JOSEPH E. GEENEN, M.D.;
- GEORGE T. HENSLEY, M.D.; and
- DANIEL H. WINSHIP, M.D.
- Requests for reprints should be addressed to Joseph E. Geenen, M.D., Racine Medical Clinic, 5625 Washington Ave., Racine, Wis.
Excerpt
There is general agreement regarding the clinical and pathological features of chronic active hepatitis (1)—lupoid hepatitis (2), plasma cell hepatitis (3), active juvenile cirrhosis (4)—but the efficacy of any type of therapy has yet to be established. Suppression of symptomatic and biochemical manifestations is often achieved during glucocorticoid administration (3-7), but proof that these drugs affect the ultimate prognosis favorably is lacking. A few recent reports (5, 8-10) suggest that some patients may benefit from the administration of purine antagonists (6-mercaptopurine, azathioprine, 6-thioguanine). In no reported case of well-established chronic active hepatitis thus treated, however, has the remission been sustained
This 100-word excerpt has been provided in the absence of an abstract.
Summario in Interlingua
Le characteristicas clinic, biochimic, e histologic de chronic hepatitis active esseva observate durante un periodo de 3 annos in un juvene femina adulte. Su responsa a glucocorticoides e a 6-mercaptopurina esseva documentate con serial tests del functionamento hepatic e biopsias hepatic. Il pare que 6-mercaptopurina evocava un sustenite remission post 2 annos de active morbo hepatic. Sex menses post le suspension del therapia, le morbo remane sin recidiva.
Article and Author Information
-
From the Departments of Medicine and Pathology, Marquette University School of Medicine and Milwaukee County General Hospital, Milwaukee, Wis.
-
- Received July 25, 1966.
- Accepted August 9, 1966.
Most Read
