The Clinical Significance of Deoxyribonucleic Acid Particles in Synovial Fluid

doi:10.1059/0003-4819-65-6-1229

The Clinical Significance of Deoxyribonucleic Acid Particles in Synovial Fluid

Requests for reprints should be addressed to Thomas J. Pekin, Jr., M.D., Division of Rheumatic Diseases, Department of Medicine, Georgetown University Medical Center,
Washington, D. C. 20007
.

Excerpt

Examination of synovial fluid has proved to be of definite value in the diagnosis of certain rheumatic conditions; but more importantly, it has led to greater understanding of the pathogenesis of some diseases affecting joints.

Renewed interest in the study of synovial fluid has been stimulated by the identification of sodium urate crystals in the synovial fluids of patients with gouty arthritis (1, 2) and has resulted in an understanding of the role of urate crystals in acute gouty inflammation (3). The finding of calcium pyrophosphate crystals in the synovial fluid of patients with pseudogout (4) has provided a rapid

This 100-word excerpt has been provided in the absence of an abstract.

Summario in Interlingua

Un studio del cytologia de specimens de liquido synovial obtenite ab patientes con arthritis rheumatoide resultava in le constatation de micre oval particulas con le tincturabilitate de acido deoxyribonucleic, locate liberemente in le liquido synovial, intra leucocytos, e adherente a leucocytic membranas cellular. Le particulas se tinctura selectivemente con le technica de Feulgen le qual es specific pro materiales de acido deoxyribonucleic. Un associate, ben que minus frequente observation in liquidos rheumatoide esseva le displaciamento peripheric del nucleo per materiales proteinic in certe leucocytos polymorphonucleari.

Pro corroborar le specificitate de iste constatationes, particulas de acido deoxyribonucleic esseva cercate in specimens de liquido synovial ab 18 patientes con arthritis rheumatoide, 19 patientes con non-rheumatoide conditiones inflammatori del articulationes, e 8 patientes con non-inflammatori effusiones articular.

Particulas de acido deoxyribonucleic in sitos extracellular, intracellular, e juxtomembranal esseva notate regularmente in effusiones synovial ab patientes con arthritis rheumatoide. Displaciamento peripheric del nucleos leucocytic esseva observate in 17 de iste 18 specimens.

Conditiones inflammatori non-rheumatoide includeva generalisate lupus erythematose, arthritis guttose, syndrome de Reiter, psoriasis con arthritis, arthritis de colitis ulcerative, e arthritis gonococcal e tuberculotic. Particulas de acido deoxyribonucleic esseva notate infrequentissimemente e non in omne le tres sitos characteristic in le liquido synovial ab tres inter 27 patientes con non-rheumatoid conditiones articular.

Le presentia de particulas de acido deoxyribonucleic in omne le tres sitos ha essite observate solmente in liquidos synovial ab patientes rheumatoide.

Article and Author Information

From the Departments of Medicine and Research Pathology, Georgetown University Schools of Medicine and Dentistry, Washington, D. C.
This study was supported by grants AM 5140 and AM 5042, U. S. Public Health Service, Washington, D. C., and by the Arthritis Foundation of Metropolitan Washington, Washington, D. C.
- Received May 13, 1966.
- Accepted May 26, 1966.