Intradermal Tests and Antinuclear Factors in Systemic Lupus Erythematosus

doi:10.1059/0003-4819-65-6-1221

Intradermal Tests and Antinuclear Factors in Systemic Lupus Erythematosus

A Comparative Study

FARIS J. AZOURY, M.D.;
HENRY E. JONES, M.D.;
VINCENT J. DERBES, M.D., F.A.C.P.; and
OREN B. GUM, M.D., PH.D.

Requests for reprints should be addressed to Faris J. Azoury, M.D., Department of Medicine, Wayne State University School of Medicine,
1400 Chrysler Freeway, Detroit, Mich. 48207
.

Excerpt

Abnormal immunological reactions have been described more frequently and in greater number in systemic lupus erythematosus (SLE) than in any other disease. A wide variety of circulating antibodies that are capable of reacting with the patient's own tissues has been identified. Among these antibodies is a group that reacts with various nuclear components. Through the wide use of the immunofluorescent technique, the antinuclear factors (ANF) have been studied extensively by many investigators. However, to date very little has been done to correlate the presence of humoral antinuclear immunoglobulins and skin reactivity to nuclear antigens in SLE.

Skin lesions are commonly

Summario in Interlingua

Tests intradermal utilisante leucocytos homologe, histona de thymo de vitello, nucleoproteina de thymo de vitello, e acido deoxyribonucleic de thymo de vitello, e tests pro factores antinucleari in le sero utilisante un indirecte technica immunofluorescentic esseva effectuate in 25 patientes con generalisate lupus erythematose. Vinto-quatro patientes esseva positive a leucocytos, 21 a nucleoproteina de thymo de vitello, 23 a histona de thymo de vitello, e 12 a acido deoxyribonucleic de thymo de vitello. Trenta-cinque subjectos de controlo esseva negative in omne le tests. Le resultatos del tests intradermal esseva correlationate con le configuration obtenite in le studio del factores antinucleari e con le stato clinic del patientes. Le 12 patientes con un reaction positive a intradermal acido deoxyribonucleic de thymo de vitello habeva active generalisate lupus erythematosa, e lor seros produceva non-lisie configurationes de factores antinucleari. Le 13 patientes con un negative reaction a intradermal acido deoxyribonucleic de thymo de vitello esseva clinicamente inactive, e lor seros revelava solmente le configuration homogenee. Iste constatationes suggestiona que positive reactiones a intradermal acido deoxyribonucleic de thymo de vitello es ben correlationate con non-lisie configurationes de factor antinucleari e clinicamente con le presentia de active generalisate lupus erythematose.

Tests intradermal esseva etiam effectuate in 6 patientes con lupus discoide. Quatro del patientes, qui subsequentemente monstrava manifestationes de dissemination sed qui esseva ancora negative pro cellulas de LE, reageva positivemente in le majoritate del tests intradermal. Le altere duo patientes non disveloppava manifestationes generalisate e habeva reactiones negative in omne le tests intradermal.

Article and Author Information

From the Section of Arthritis, Department of Medicine, Section of Allergy and Dermatology, Department of Medicine, Tulane University School of Medicine, New Orleans, La., and the Section of Rheumatology, Department of Medicine, Wayne State University School of Medicine, Detroit, Mich.
This work was supported in part by grant TI AM 5005, the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Md.
- Received May 6, 1966.
- Accepted August 31, 1966.