Dietary Protein Deficiency
Its Influence on Body Structure and Function
- J. F. BROCK, D.M., F.R.C.P., F.A.C.P.
- Requests for reprints should be addressed to J. F. Brock, D.M., at the above South African address.
Excerpt
The middle of the twentieth century saw one of those peculiar "conjunctions" between the fields of pure nutritional science and of applied nutritional policy which Mr. Punch would have called "another glimpse of the obvious." But it only became "obvious" after the event. In spite of much accumulation of knowledge of protein chemistry and of the role of nitrogen and amino acids in experimental and applied animal nutrition, the message was somehow lost in its application to human health and welfare. The reason for this was probably dazzlement by the remarkable scientific advances in knowledge of vitamins. As a result,
This 100-word excerpt has been provided in the absence of an abstract.
Acknowledgments
In acknowledging with gratitude the honorary Fellowship conferred on me by the American College of Physicians, I take the opportunity to acknowledge my indebtedness, since 1932, to many persons, institutions, and foundations in the U. S. A. to whom or to which I owe thanks for hospitality and stimulus.
Most of the local work reviewed in this lecture has been part of the program of the Clinical Nutrition Research Unit supported in the Department of Medicine at the University of Cape Town by the South African Council for Scientific and Industrial Research. Additional financial assistance has been received from the Williams Waterman Fund for the Combat of Dietary Diseases, New York, N. Y., from the Food and Nutrition Board, National Research Council of the United States of America, and from the National Institutes of Health under grant AM 03995 (NTN). I acknowledge also a deep debt of gratitude to many colleagues who have been associated with me in these studies. Their names are recorded in the references cited.
Summario in Interlingua
Le requirimento de un ordinate disposition de sequentias de aminoacido in catenas polypeptidic sublinea le importantia de octo o plus aminoacidos "essential" que non es synthetisate per le corpore human e, per consequente, debe esser providite regularmente in le dieta.
Es presentate un breve revista del historia de proteina in studios nutritional, de Mehlnährschaden (effectos adverse de nutrimento hyperfarinacee) como ancian problema de pediatria, de kwashiorkor, e del recognition international (1949-1953) de "malnutrition proteinic" como "le plus grave e plus extense disordine dietari ancora existente in le mundo."
Homines de medicina clinic e laboratorial ha recgnoscite in iste problemas le opportunitate tanto pro productive recercas applicate e pro recercas fundamental relative al interaction mutual de nutrientes producente energia e alteres. Typic de iste ultime conception es le reimplaciamento del termino "malnutrition proteinic" per "malnutrition in calorias ab proteina."
Es summarisate brevemente le evidentia experimental que supporta le rolo primari e dominante de carentia de un gruppo de essential aminoacidos in le etiologia e pathogenese de kwashiorkor. Recente labores es summarisate, incluse contributiones significative facite per recercatores con qui io ha habite le privilegio de laborar. Le effectos de malnutrition de calorias ab proteina super le integritate e le function de multe systemas del corpore human comencia a render se al attaco del recerca clinic. Modellos animal es currentemente sub studio per varie gruppos. Illos va certo elucidar numerose aspectos del physiologia nutritional que es ancora obscur.
Certe simplissime parametros clinic e de sanitate public permitte hodie le certe detection de un prevalentia de insalubre nutrition hyperamylose in populationes pediatric. Iste parametros appare in simple statisticas de crescentia e de morbiditate resultante ab le insufficente resistentia a extensemente prevalente microorganismos.
Article and Author Information
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From the Department of Medicine, University of Cape Town Medical School, Observatory, Cape, South Africa.
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- Received July 7, 1966.
- Accepted July 22, 1966.
- Copyright ©, 1966, by The American College of Physicians
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