RSS Feeds
Ampicillin in the Treatment of Enterococcal Endocarditis
- HARRY N. BEATY, M.D.;
- MARVIN TURCK, M.D.; and
- ROBERT G. PETERSDORF, M.D., F.A.C.P.
- Requests for reprints should be addressed to Harry N. Beaty, M.D., King County Hospital, 325 9th Ave., Seattle, Wash. 98104.
Excerpt
The currently recommended treatment for enterococcal endocarditis consists of high doses of aqueous penicillin intravenously, given in combination with intramuscular streptomycin for 6 weeks (1). If antibiotic dosage is regulated to maintain a constant bactericidal activity against the infecting strain in at least a 1:4 dilution of the patient's serum, the bacteriologic cure rate for this infection approaches that achieved for highly penicillin-sensitive Streptococcus viridans endocarditis (1, 2). Although the penicillin-streptomycin regimen is eminently satisfactory from the therapeutic point of view, it involves considerable inconvenience, cost, and the potential risk of ototoxicity. For these reasons, it seems reasonable to seek
This 100-word excerpt has been provided in the absence of an abstract.
Summario in Interlingua
Un comparation del susceptibilitate in vitro de enterococcos pro penicillina G con illo del mesme organismos pro ampicillina esseva effectuate a base de 25 recente isolatos de enterococcos. Ampicillina se provava constantemente como plus fortemente bactericida que penicillina G pro le majoritate del isolatos. Le experientias de plure laboratorios relative al sensibilitate in vitro de enterococcos pro ampicillina esseva revistate e se monstrava in congruentia con le resultatos del presente studio in tanto que plus que 90 pro cento del lineas esseva inhibite per concentrationes practicabile in le sanguine. Ampicillina pare esser un efficace agente bactericida que ha essite usate a bon successo in le tractamento de serie infectiones enteroococcal, incluse un patiente con endocarditis enterococcal reportate in le presente communication. Il es clar que ampicillina—quando su uso es appropriatemente regulate per medio de tests del bactericidialitate in sero—es capace a effectuar un curation bacteriologic de endocarditis enterococcal e representa, possibilemente, un convenibile, relativemente incostose, e non-toxic alternativa pro le establite regime a penicillina e streptomycina.
Article and Author Information
-
From the Department of Medicine, University of Washington School of Medicine, and King County Hospital, Seattle, Wash.
-
This study was supported in part by a grant from the Boeing Good Neighbor Fund.
-
- Received April 15, 1966.
- Accepted April 29, 1966.
Related Clinical Content
