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False Neurochemical Transmitters
Combined Clinical Staff Conference at the National Institutes of Health
- ROBERT A. COHEN, M.D.;
- IRWIN J. KOPIN, M.D.;
- CYRUS R. CREVELING, PH.D.Bethesda, Maryland ;
- JOSE M. MUSACCHIO, M.D.New York, New York ;
- JOSEF E. FISCHER, M.D.Boston, Massachusetts ;
- J. RICHARD CROUT, M.D.Dallas, Texas ; and
- JOHN R. GILL, JR., M.D.Bethesda, Maryland
- Requests for reprints should be addressed to Robert A. Cohen, M.D., Clinical Director, National Institute of Mental Health, Bldg. 10, Rm. 3-N-234, National Institutes of Health, Bethesda, Md. 20014.
Excerpt
Dr. Robert A. Cohen: Until the happy day when someone comes up with a truly integrated theory, our Institute has followed the pattern of presenting alternately studies of psychosocial and biological aspects of behavior. In this Conference it is the turn for one of the latter. Dr. Irwin J. Kopin, Chief of the Section on Medicine, Laboratory of Clinical Science, National Institute of Mental Health, will report on some of his work relating to the sympathetic nervous system. Dr. Kopin has been interested in the synthesis, storage, release, metabolism, and mode of action of the biogenic amines and has studied
Summario in Interlingua
Impulsos de nervo sympathic evoca responsas in organos effectori per liberar le specific substantia chimic norepinephrina que es thesaurisate in vesiculos synaptic del terminos neural.
Le enzyma responsabile pro le conversion de dopamina ad in norepinephrina es relativemente nonspecific e converte un varietate de phenylethylaminas in lor derivatos β-hydroxylate. Iste analogos de norepinephrina pote esser retenite—con varie grados de affinitate in dependentia de lor structura chimic—al sitos de thesaurisation de norepinephrina in le terminos neural, e illos es liberate per stimulation neural como "false transmissores neurochimic". Illos reimplacia un parte del norepinephrina liberate per le impulso neural e es generalmente minus active in evocar responsas in le organo effectori que le ver transmissor, con le resultato de un reducite responsivitate sympathic.
Le signification del mechanismo de false transmissores in le pharmacologia human trova un illustration in le reducite responsivitate sympathic que es a notar post le administration de metaraminol o de parahydroxyamphetamina. Iste α-methylaminas non es destruite per oxidase monoaminic e augmenta le tension de sanguine quando lor concentrationes in le plasma suffice a liberar norepinephrina ab le terminos sympathico-neural sed pote resultar in un declino del tension de sanguine quando lor accumulation progrede lentemente.
Quando le activitate de oxidase monoaminic es inhibite, aminas endogene—specialmente octopamina—se accumula in le terminos sympathico-neural. Le liberation de un false transmissor (octopamina), le qual displacia le norepinephrina liberate per impulsos de nervos sympathic, explica possibilemente le reducite responsivitate sympathic que se observa quando patientes es tractate con inhibitores de oxidase monoaminic.
Article and Author Information
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This is an edited transcription of a combined clinical staff conference at the Clinical Center, Bethesda, Md., by the National Institute of Mental Health, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare.
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- Received May 11, 1966.
- Accepted May 23, 1966.
