RSS Feeds
Metabolic Abnormalities of Lactic Acid in Burkitt-type Lymphoma with Malignant Effusions
- JEROME B. BLOCK, M.D.;
- WILLIAM R. BRONSON, M.D.; and
- WILLIAM R. BELL, M.D.
- Requests for reprints should be addressed to Jerome B. Block, M.D., Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md. 20014.
Excerpt
Elevations of blood lactic acid rarely are observed in patients with cancer uncomplicated by shock or hypoxia. However, Field, Block, and Rall (1) and Field, Block, Levin, and Rall (2) noted an occasional relationship between extensive leukemia and development of clinical lactic acidosis. They suggested that lactic acid produced by leukemic tissue may be the cause of such a metabolic disorder although leukemic cells are paradoxically characterized by low in vitro rates of glycolysis (2-6), in contrast to most malignant neoplasms (7-10).
Recently, a patient with "Burkitt's lymphoma" was admitted to the National Cancer Institute. The initial manifestations of the
This 100-word excerpt has been provided in the absence of an abstract.
Acknowledgment
The authors are indebted to Dr. E. Vesell for starch block electrophoresis studies of lactic acid dehydrogenase and to Dr. P. Burke and A. Serpick for their co-operation.
Summario in Interlingua
Hyperacidemia lactic es observate rarmente in patientes con cancere sin choc o hypoxia. Un patiente con lymphoma bilatero-ovarian histologicamente identic con tumor de Burkitt manifestava elevate nivellos sanguinee de acido lactic sed esseva libere del causas usual de un tal augmento. Le curso clinic esseva characterisate per recurrente effusiones maligne accompaniate de hyperacidemia lactic. Studios simultanee de sanguine arterial e de specimens del effusiones maligne demonstrava acidosis del effusiones (pH 7,11 — 7,28) con concentrationes de acido lactic duo a tres vices plus forte (7 a 12 mEq/L) que in le sanguine (1,7 a 3,4 mEq/L). Simile studios in 6 patientes de controlo con effusiones de altere etiologias non revelava comparabile differentias inter effusion e sanguine quanto al iones de H+ o al acido lactic. Le nitrogeno del urea e le electrolytos non monstrava ulle correspondente differentia in le patiente con lymphoma o in le patientes de controlo.
Viabile lymphoblastos maligne ab le effusiones del patiente esseva incubate in liquido histocultural a 37 C sub conditiones aerobie e anaerobie. Le production aerobie de acido lactic esseva 2,0 µMol per minuta per 109 cellulas o, pro le patiente describite, 230 mMol per die. Iste observationes suggere que le production de acido lactic per le tumor resultava in exceptional gradientes biochimic inter effusiones e sanguine e esseva de un magnitude sufficiente pro producer hyperacidemia lactic.
Article and Author Information
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From the Medicine Branch, National Cancer Institute, and the Clinical Pathology Department, Clinical Center, National Institutes of Health, Bethesda, Md.
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- Received January 17, 1966.
- Accepted January 25, 1966.
