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Cholera
Combined Clinical Staff Conference at the National Institutes of Health
- ROBERT S. GORDON, JR., M.D.;
- JOHN C. FEELEY, PH.D.;
- WILLIAM B. GREENOUGH III, M.D.Bethesda, Maryland ;
- COL. HELMUTH SPRINZ; and
- ROBERT OSEASOHN, M.D.
- Requests for reprints should be addressed to Robert S. Gordon, Jr., M.D., Clinical Director, National Institute of Arthritis and Metabolic Diseases, Bldg. 10, Room 9-N-222, National Institutes of Health, Bethesda, Md. 20014.
Excerpt
Dr. Robert S. Gordon, Jr.: Cholera is an acute diarrheal disease with high mortality, if untreated. Spreading from Asia, it swept Europe with devastating pandemics in the nineteenth century (1). The conquest of cholera was one of the first triumphs of scientific medicine and did much to establish in the public mind the value of environmental sanitation. During the first half of this century, cholera received but little scientific attention, having been largely confined to its endemic home in Bengal. The past decade has seen a marked increase in both the number of cases and in the geographic areas affected.
This 100-word excerpt has been provided in the absence of an abstract.
Acknowledgment
The help and encouragement of Brigadier General Joe M. Blumberg (MG), The Director, Armed Forces Institute of Pathology, is greatly appreciated.
Summario in Interlingua
Cholera, reguardate usque satis recentemente como "conquerite" per le scientia medical, ha comenciate redevenir un menacia in multe areas del mundo ubi le population es dense e le sanitation inadequate. Le decennio passate ha vidite un augmento in le numero del subjectos afficite e etiam in le extension geographic del morbo. Ha etiam occurrite un resurgentia del interesse in recercas scientific relative al tractamento e al prevention de cholera. In le presente colloquio, importante progressos de data recente es revistate per investigatores le quales ha participate in ille disveloppamentos. Disturbationes de fluido e electrolytas in cholera clinic explica le mortalitate associate con le condition, sed istos es factores que pote esser manipulate si satisfactorimente que omne patiente deberea superviver si ille recipe un appropriate attention therapeutic. Per medio de antibioticos, le duration del morbo se reduce al minimo. Studios bacteriologic promitte revelar le substantia toxic per medio del qual le vibrion de cholera produce diarrhea. Le effecto de iste toxina super le hospite require investigationes additional ab le puncto de vista anatomic como etiam ab le puncto de vista functional. Le valor del immunisation prophylactic contra cholera—longemente acceptate sin question in despecto del absentia de omne prova objective—ha recentemente essite demonstrate pro le prime vice in un essayage a controlo in circumstantias natural. Ben que vaccino contra cholera in su presente constitution pote reducer le incidentia de cholera clinic per approximativemente 80 pro cento, illo causa adverse effectos secundari, protege probabilemente solmente durante un restringite periodo de tempore, e es forsan sin valor in eliminar le stato de vector. Si nos vole eradicar cholera, recercas additional e meliorationes technologic va esser requirite, particularmente quanto al methodos de prevention. Il es possibile que le continue studio del pathophysiologia de cholera va discoperir information de valor, non solmente relative al melioration del tractamento pro cholera sed etiam relative al promotion de nostre comprension del physiologia gastrointestinal de cholera mesme e de altere morbos intestinal e metabolic.
Article and Author Information
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This is an edited transcription of a combined clinical staff conference at the Clinical Center, Bethesda, Md., by the National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare.
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- Received March 11, 1966.
- Accepted March 18, 1966.
