Isolated Lactase Deficiency Producing Postgastrectomy Milk Intolerance
- JACK D. WELSH, M.D.;
- ROBERT W. SHAW, B.S.; and
- ANTHONY WALKER, B.S.
- Requests for reprints should be addressed to Jack D. Welsh, M.D., Department of Medicine, University of Oklahoma Medical Center, 800 NE 13th St., Oklahoma City, Okla. 73104.
Excerpt
The ingestion of milk and milk products may precipitate postprandial symptoms in some patients after gastric surgery for peptic ulcer disease (1). Milk allergy (2), location of the gastrojejunal anastomosis (3), and intestinal lactase deficiency (4) have been suggested as possible causes. Two patients whose postgastrectomy symptoms were associated with an isolated lactase deficiency were subjects of an earlier report (5). The present investigation expands these observations and evaluates lactose tolerance tests and the intestinal disaccharidase activity in a group of 24 patients who underwent gastric surgery.
MATERIAL AND METHODS PATIENTS
Out of all the subjects, 19 males and 5
This 100-word excerpt has been provided in the absence of an abstract.
Acknowledgments
We are indebted to Dr. G. V. Rohrer for aiding with some of the studies and to Lois Russell, Gary Schwab, and Juanetta Anderson for their technical assistance.
Summario in Interlingua
Vinti-quatro patientes qui habeva experientiate varie interventiones chirurgic pro ulcere peptic esseva subjicite a tests de tolerantia pro lactosa. Dece-novem absorbeva lactose de maniera normal e habeva un valor medie del augmento maximal de sucro sanguinee supra le nivello in stato jejun de 110 mg/100 ml (con un campo de variation ab 38 ad 191). Vinti-tres specimens intestinal ab 13 del subjectos in iste gruppo esseva subjicite a essayage, e le valor medie del activitate intestinal de lactase esseva 42 unitates per gramma de proteina (con un campo de variation ab 16 ad 82). In le remanente 5 patientes, le absorption de lactosa esseva anormal, con un valor medie del augmento de sucro sanguinee de 14 mg/100 ml (con un campo de variation ab 11 ad 19). Le valor medie del activitate intestinal de lactase in 9 specimens ab iste 5 patientes esseva 6 unitates per gramma de proteina (con un campo de variation ab 4 ad 8). Le activitates de sucrase, de maltase, de palatinase, e de phosphatase alcalin esseva simile in le duo gruppos. Le isolate carentia de lactase resultante in non-tolerantia pro lacte in le 5 patientes non poteva esser attribuite a differentiae in le typos de chirurgia experientiate. Le tolerantia pro glucosa, le tolerantia pro glucosa e galactosa, e le excretion de d-xylosa esseva comparabile in le duo gruppos, e le mesmo valeva pro le resultatos de mesurationes del villos intestinal e del altor del cellulas de epithelio superficial. Duo del patientes con carentia de lactase habeva steatorrhea, sed le relation inter iste condition e nontolerantia pro lactosa non es clar.
Article and Author Information
-
From the Department of Medicine, the University of Oklahoma Medical Center, Oklahoma City, Okla.
-
This study was supported in part by training grant TI AM 5179-06 from the National Institutes of Health, Bethesda, Md.
-
- Received January 13, 1966.
- Accepted February 2, 1966.
Related Clinical Content
Most Read
