Clinical and Epidemiological Features of Coxsackie Group B Virus Infections
- Requests for reprints should be addressed to Malcolm S. Artenstein, M.D., Assistant Chief, Department of Virus Diseases, Walter Reed Army Institute of Research, Washington, D. C. 20012.
Excerpt
Since Dalldorf and Sickles (1) first described Coxsackie viruses in 1948, 30 distinct serotypes have been identified. Twenty-four are classed in group A and six in group B by characteristic pathology produced by infection of the suckling mouse (2, 3). Since then the group A viruses have been found to cause herpangina and central nervous system disease of varied clinical manifestations (3, 4). The group B viruses have generally been recognized to produce epidemics of aseptic meningitis and pleurodynia and to cause encephalomyocarditis in infants. The group B Coxsackie viruses have also been implicated in a number of other clinical
This 100-word excerpt has been provided in the absence of an abstract.
Acknowledgments
Miss N. Rogers, Mr. G. Holmes, and Mr. O. Dandridge provided expert laboratory assistance.
Summario in Interlingua
Depost le reporto de lor discoperta in 1948, trenta distincte serotypos de virus Coxsackie ha essite describite. Virus Coxsackie gruppo A ha essite relationate causalmente con le syndromes de herpangina e meningitis aseptic. Le virus gruppo B, sex in numero, ha essite recognoscite como causa de epidemias de pleurodynia e meningitis aseptic e de encephalomyocarditis de infantes. In plus, numerose reportos ha incriminate virus Coxsackie gruppo B in casos sporadic de acute pericarditis benigne, de myocarditis, de infection poliomyelitoide, e de orchitis.
Con le objectivo de provider un certe assistentia in le diagnose clinic, un revista esseva facite de 180 laboratorialmente confirmate casos de infection a virus Coxsackie gruppo B.
Le significative characteristicas epidemiologic de iste casos esseva le distribution in estate e autumno e le predominantia de un sol serotypo in un anno particular.
In iste serie, le sequente syndromes clinic esseva observate: meningitis aseptic (64%), pleurodynia (21%), anxietate abdominal (4%), lesiones oral (3%), myocarditis (4%), pericarditis (3%), myalgia (4%). Exanthema orchitis, e febrilitate non-specific esseva diagnosticate in minus que 2 pro cento del patientes cata-un.
Le etate del patientes pareva haber un rolo determinante quanto al typo del syndrome clinic producite per le virus Coxsackie gruppo B. Cinque infantes con myocarditis moriva, sed le duo adultos con affection del myocardio esseva solo levemente malade. Cinque patientes habeva pericarditis, e illes omnes esseva adultos mascule. Ben que dolores abdominal occurreva le plus frequentemente in juveniles de etates de minus que 10 annos, pleurodynia esseva diagnosticate infrequentemente in iste gruppo de etate.
Un diagnose clinic de infection a virus Coxsackie gruppo B pote esser facite con alte grados de successo sub le sequente circumstantias: (1) epidemias de pleurodynia; (2) meningitis aseptic, orchitis, pericarditis, exanthema, dolores abdominal, etc., occurrente in subjectos exponite a un patiente con pleurodynia; (3) myocarditis neonatal. In climates temperate, infectiones a virus Coxsackie gruppo B es rar excepte durante le menses del estate e del autumno.
Article and Author Information
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From the Department of Virus Diseases, Walter Reed Army Institute of Research, Washington, D. C.
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- Received April 5, 1965.
- Accepted May 21, 1965.
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