Cushing's Syndrome Due to Islet Cell Carcinoma of the Pancreas

doi:10.1059/0003-4819-63-1-58

Cushing's Syndrome Due to Islet Cell Carcinoma of the Pancreas

Report of Two Cases: One with Elevated 5-hydroxyindole Acetic Acid and Complicated by Aspergillosis

Requests for reprints should be addressed to Bettye A. Sayle, M. D., Department of Internal Medicine, The University of Texas Medical Branch,
Galveston, Texas
.

Excerpt

Adrenocortical hyperplasia associated with nonpituitary neoplasms is a well-known clinical entity. Twelve cases due to carcinoma of the pancreas have been reported (1-12). Of these, there were five adenocarcinomas (1-5), six islet cell carcinomas (6-11), and one ductal carcinoma (12). The purpose of this report is to record two additional cases of Cushing's syndrome with islet cell carcinoma of the pancreas and some unusual associated findings.

CASE REPORTS CASE 1

J. P., a 62-year-old white female, was admitted to The John Sealy Hospital on October 24, 1958, with a diagnosis of Cushing's syndrome. In May, 1958, she had the onset

This 100-word excerpt has been provided in the absence of an abstract.

Summario in Interlingua

Es presentate duo casos de syndrome de Cushing causate per carcinoma de cellulas insulari del pancreas. Dece-duo previemente reportate casos es revistate. Le characteristicas del morbo es discutite. Es signalate le absentia de multes del manifestationes usual de syndrome de Cushing causate per primari hyperplasia adrenocortical.

Aspergillosis complicava le prime del duo casos. Iste condition ha non previemente essite identificate in tal patientes. Un augmentate excretion de acido 5-hydroxyindolacetic in le absentia de un demonstrabile tumor carcinoide esseva etiam constatate in le prime caso. Es commentate le possibilitate que le tumor pancreatic produceva duo hormones.

Le secunde patiente es le plus juvene usque nunc reportate. Un elevate activitate adrenocorticotrophino-simile esseva demonstrate in le tumor ab iste patient.

Article and Author Information

From the Endocrine and Metabolic Service, Department of Internal Medicine, and The Department of Pathology, The University of Texas Medical Branch, Galveston, Texas.
- Received December 18, 1964.
- Accepted January 19, 1965.