Cytomegalic Inclusion Disease in Patients with Acute Leukemia

doi:10.1059/0003-4819-62-5-899

Cytomegalic Inclusion Disease in Patients with Acute Leukemia

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Excerpt

Cytomegalic inclusion disease (CID), the result of infection with the salivary gland virus (SGV), has been reported frequently as a cause of morbidity and mortality in newborns and infants. However, less than 60 infections have been reported in adults, where it usually occurs as a complication of chronic, debilitating diseases, especially hematologic malignancies (1-7). Since there is no pathognomonic constellation of signs and symptoms in the adult, CID is rarely diagnosed antemortem.

Recently, the diagnosis of CID was established in 13 acute leukemia patients at the Clinical Center of the National Institutes of Health. Eleven of these patients died within

This 100-word excerpt has been provided in the absence of an abstract.

Summario in Interlingua

Durante le periodo ab 1953 a 1963, examines necroptic resultava in le discoperta de morbo a inclusiones cytomegalic in 13 patientes con leucemia acute. Isto representa un incidentia de 3 pro cento relative al total de 394 necropsias effectuate in patientes con leucemia acute al Institutos National de Sanitate. Infection a virus de glandula salivari esseva le causa de morte in tres del patientes. Ille 13 patientes con morbo a inclusiones cytomegalic esseva comparate con un gruppo de controllo appareate con respecto a etate e sexo. Le cursos clinic del patientes in le duo gruppos esseva simile. Nulle symptomas esseva notate, e nulle signos physic o constatationes laboratorial que haberea potite suggerer le presentia de morbo a inclusiones cytomegalic.

Le pulmones esseva inficite con virus de glandula salivari in omne le patientes e le vias gastrointestinal in 11. In un patiente le pulmon esseva le sol sito de cellulas a inclusiones cytomegalic. Le morbo esseva extensemente disseminate in cinque patientes. In tres de istes illo esseva le causa de morte. In un patiente, cellulas a inclusiones cytomegalic esseva identificate in 15 differente sitos.

Dece-un del 13 patientes con morbo a inclusiones cytomegalic moriva intra un periodo de 13 menses, lo que suggere que un epidemia habeva occurrite. Octanta pro cento de iste 11 episodios occurreva in juveniles de etates de minus que dece annos. Solmente 30 pro cento del juveniles in iste gruppo de etate habeva significative titros de anticorpore a fixation de complemento contra virus de glandula salivari. Iste duo factos supporta le conception que morbo a inclusiones cytomegalic associate con leucemia superveni como un infection primari.

Article and Author Information

From the Medicine Branch and Department of Pathological Anatomy, National Cancer Institute, National Institutes of Health, Bethesda, Md.
Dr. Levin died on July 9, 1964.
- Received October 27, 1964.
- Accepted November 30, 1964.