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A Clinical Evaluation of Plasma Thromboplastin Antecedent (PTA) Deficiency
- FRED G. CONRAD;
- WILLIAM L. BRENEMAN; and
- DOROTHY B. GRISHAM, B.S.
- Requests for reprints should be addressed to Maj. Fred G. Conrad, USAF (MC), Wilford Hall USAF Hospital, Lackland AFB, Tex. 78236.
Excerpt
Since Rosenthal, Dreskin, and Rosenthal (1) first described plasma thromboplastin antecedent (PTA) deficiency 10 years ago, investigators from numerous hematology centers have emphasized the infrequent occurrence of this defect. Reports of the relative rate of occurrence of patients deficient in antihemophilic factor (AHF) and plasma thromboplastin component (PTC) are remarkably stable at a 4 to 1 ratio in this country and throughout the world (2-4). The reports of relative occurrence of PTA show marked variations from less than 1% to 18% of the total thromboplastinogen disorders (5-8).
Contrary to the usually reported low incidence, our studies indicate that PTA deficiency
Summario in Interlingua
Le incidentia de carentia de antecedente de thromboplastina plasmatic (ATP) es reportate multo differentemente in differente publicationes, sed omne investigatores es de accordo in notar que illo es le minus commun del defectos de thromboplastogeno. Per contrasto con le majoritate del previemente publicate reportos, le presente studio indica que carentia de ATP es le plus commun del disordines hemophiliac o hemophilia-simile. Anormalitate del prime stadio coagulatori—sin contar disordines plachettal o statos paraproteinemic—esseva identificate in le curso del passate tres annos in 8 subjectos vidite al hospital Wilford Hall del Statounitese Fortias Aeree. In 14 del casos il se tractava de un carentia de factor antihemophiliac, in tres de un carentia de componente thromboplastinic de plasma, e in 65 de un carentia de ATP.
Observationes colligite in le curso del evalutation del mentionate 65 patientes con carentia de ATP representante 43 familias supporta le conception que le modo de hereditage es characterisate per dominantia autosomal con grados moderate de variabilitate in le expression del gen.
Let tests de discrimination preliminari, le quales se usa communmente ante un operation, haberea monstrate resultatos normal in 34 pro cento del patientes con carentia de ATP. Il es probabile que solmente un correctemente effectuate test del generation de thromboplastina—per un technologo con matur experientias in le application de iste test—es sufficientemente sensibile pro demonstrar fidelmente le presentia de un stato de carentia de ATP. Le grado de prolongation del test de generation de thromboplastina revelava nulle correlation con le grado de symptomas clinic.
Carentia de ATP pote esser totalmente asymptomatic. Tamen, in despecto de su benignitate sub conditiones normal, illo pote resultar in excessos de sanguination post operationes chirurgic, post extractiones de dentes, o post trauma accidental.
Le characteristica inusual de un reversion apparente a comportamento normal que es observate in plasma a carentia de ATP post immagasinage a -20° C es probabilemente un reflexion del lente progression del reducite ATP presente in le plasma de iste patientes verso le formation de producto de activation.
Article and Author Information
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From the Department of Medicine, Wilford Hall U. S. Air Force Hospital, Aerospace Medical Division, Lackland Air Force Base, Tex.
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- Received October 10, 1964.
- Accepted November 30, 1964.
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