Hematodepressive Virus Diseases of Thailand

  1. HOWARD R. BIERMAN, M.D.; and
  2. ETHEL R. NELSON, M.D.
  1. Requests for reprints should be addressed to Howard R. Bierman, M.D., Institute for Cancer and Blood Research,
    321 S. Robertson Blvd., Beverly Hills, Calif. 90211

Excerpt

In 1951, an acute febrile hemorrhagic disease with high mortality was recognized to occur sporadically in the vicinity of Bangkok, Thailand. The condition was originally considered to be a severe viral influenza characterized by shock or thrombocytopenic purpura, or both (1), but influenza virus was not isolated from these patients. Recurrent episodes in the Philippines of a disease with hemorrhagic phenomena were described in 1953 by Stransky and Dacanay (2). In 1954, epidemics of a similar disease occurred in Manila and in Bangkok. The disease was tentatively named Philippine hemorrhagic fever and subsequently Thai hemorrhagic fever to distinguish it from

Summario in Interlingua

1. Esseva studiate sub le conditiones de un hospital 681 patientes thai con constatationes clinic de un morbo a virus hematodepressive.

2. Observationes serologic revelava multiple typos de infection a virus—chikungunya, febre hemorrhagic de Thai causate per Typos III a VI de dengue (dengue pediatric), a dengue classic causate per Typos I e II in adultos. Un quarte gruppo de patientes con symptomas identic habeva nulle evidentia serologic de infection currente per dengue o chikungunya.

3. Thrombocytopenia esseva marcate in le patientes hemato-deprimite e esseva causate per precoce suppression de megacaryocytopoiese, possibilemente como primari objectivo hematopoietic. Isto esseva particularmente tal in le patientes adulte con dengue classic como etiam in casos de febre hemorrhagic de Thai (dengue pediatric), e morbo a virus hematodepressive. Chikungunya non cauava ulle profunde thrombocytopenia ben que illo causava frequentemente leve grados de ille condition.

4. Un composite ordine chronologic del evenimentos esseva reconstruite ab le longevitates del plachettas e neutrophilos polymorphonucleari, indicante inoculation de virus octo dies (±2) ante le acute declaration clinic e febril de iste morbos hematodepressive.

5. Infectiones a virus de dengue non es innocue in juveniles; le mortalitate amonta al media a 8 pro cento.

6. Anormal formas megacaryocytic persiste in le medulla durante septimanas post que le hematologia peripheric ha retornate al stato normal. Studios de patientes con mutantes megacaryocytic e granulocytic in tal morbos a virus hematodepressive es requirite pro determinar possibile diatheses al subsequente disveloppamento de plus serie morbos.

Article and Author Information

  • From the Institute for Cancer and Blood Research, Beverly Hills, Calif., the Bangkok Sanitarium and Hospital, Bangkok, Thailand, and the Departments of Medicine, Loma Linda University, and Cedars-Sinai Medical Center, Los Angeles, Calif.

    • Received October 9, 1964.
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  1. Ann Intern Med May 1, 1965 vol. 62 no. 5 867-884
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