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A Study of the Juxtaglomerular Body in Primary Aldosteronism
- Requests for reprints should be addressed to Captain Richard J. Cohen, MC, Box 66, Letterman General Hospital, San Francisco, Calif. 94129.
Excerpt
It has been postulated recently that an interdependent system involving renin, angiotensin, and aldosterone may be involved in the production of certain types of human hypertension (1, 2). A number of studies have demonstrated an interaction of renin with angiotensin I to form angiotensin II (3-5), which stimulates aldosterone secretion by the zona glomerulosa of the adrenal cortex (3, 6-8). Aldosterone, by means of its potent mineralocorticoid effect on sodium and potassium balance, produces an elevation in systemic arterial blood pressure (2-9). The use of microdissection (10-13) and fluorescent antibody techniques (14) has localized renin production to the juxtaglomerular body
Acknowledgments
We wish to thank Dr. Edward G. Biglieri and Dr. Paul E. Slaton of the Clinic Study Center, San Francisco General Hospital, for performing the aldosterone double-isotope-derivative assays and the chromium51 blood volume determination, and Major O'Neill Barrett for his technical guidance and encouragement.
Summario in Interlingua
Multe recente investigationes laboratorial e clinic es dedicate al corpore juxtaglomerular del ren. Hyperplasia e hypergranularitate del cellulas juxtaglomerular esseva trovate in association con unilateral stenosis reno-arterial e con sever arteriolonephrosclerosis. Definite augmentos del nivellos urinari de aldosterona esseva notate in tal patientes e etiam in patientes con hypertension maligne accompaniate de characteristicas que simula multo directemente illos de aldosteronismo primari causate per un tumor adrenal.
Le reportos de solmente duo documentate casos de aldosteronismo primari mentiona granularitate del cellulas juxtaglomerular. Le presente reporto concerne un patiente con un tumor a secretion de aldosterona in qui un biopsia aperte de ambe renes esseva executate al tempore del excision chirurgic del tumor. Un meticulose evalutation del corpores juxtaglomerular per medio del tres technicas que es currentemente disponibile revelava un marcate declino in le numero del cellulas e etiam un quasi complete absentia de granularitate. On ha trovate que le cellulas del corpore juxtaglomerular responde a alterationes del natrium seral e a alterationes in le volumine e le tension del sanguine. Le presentia de un alte nivello de natrium seral, plus un augmento del volumine de plasma con le resultato de hypertension que es notate in casos de aldosteronismo primari es offerite como explication del frappante alterationes constatate in le corpore juxtaglomerular. Es sublineate le importantia de biopsia renal e de analyses del corpore juxtaglomerular renal in le diagnose differential de hyperaldosteronismo.
Article and Author Information
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From the Department of Medicine and the Pathology Service, Letterman General Hospital, San Francisco, Calif.
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- Received June 29, 1964.
- Accepted September 3, 1964.
