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Alimentary Hypersensitivity Induced by Giardia Lamblia
Report of a Case of Acute Meat Intolerance
- SCOTT B. HALSTEAD, M.D.; and
- ELVIO H. SADUN, SC.D.
- Requests for reprints should be addressed to Elvio H. Sadun, Sc.D., Department of Medical Zoology, Walter Reed Army Institute of Research, Washington, D. C. 20012.
Excerpt
An intestinal flagellate usually inhabiting the duodenum, Giardia lamblia, has often been associated with abdominal discomfort and mucoid diarrhea. Although this parasite has not been proved to be pathogenic and no histologic lesions have been shown to be caused by it, a number of reports have appeared in the literature suggesting a causal relationship of this parasite with a variety of gastrointestinal syndromes, predominantly diarrhea (1-5). Recent reviews of the literature are found in articles by Wanner, Atchley, and Wasley (1) and Cortner (2).
This case report associates an abdominal discomfort syndrome with Giardia infection and ingestion of meat of
This 100-word excerpt has been provided in the absence of an abstract.
Acknowledgment
The authors wish to thank Col. Benjamin H. Sullivan, MC, Chief, Gastroenterology Service, and Capt. Eugene J. Gangarosa, MC, of the Walter Reed Army Hospital for their assistance in the work up and management of the patient, and Maj. Ray A. Olsson, MC, for suggestions for the improvement of the manuscript.
Summario in Interlingua
Es reportate le caso de un adulto mascule, inficite con Giardia lamblia, qui experientiava episodios de dolores abdominal meso-epigastric de eructation, de sudor, e de vertigine un a tres horas post repastos continente carne de origine mammalian. Aves, conchylios, hydrato de carbon, ovos frigite, caule, cucumeres, caffe, e the causava nulle symptomas. Antispasmodicos esseva inefficace in alleviar le dolores, sed aspirina esseva altemente efficace. Le symptomas dispareva post le eradication del parasito ab le intestinos e se re-manifestava 7 septimanas post le re-infection experimental. Biopsia duodenal durante le infection monstrava marcate infiltration del lamina proprie con eosinophilos e plasmocytos. Biopsia 4 menses post le eradication del parasito esseva normal. Durante le infection, le excretion de trioleina a I131 e le absorption de xylosa esseva normal. Le mesmo valeva pro series gastrointestinal e del vesica biliari, pro studios del chimia hepatic, pro analyses del urina, e pro complete hematogrammas. Post le eradication del secunde infection, le patiente esseva sin symptomas durante 3 annos de observation.
Es proponite como explication que productos excretori de Giardia lamblia effectua un directe sensibilisation de tissus duodenal o functiona como haptenes pro productos de carne mammalian de maniera que un reaction de hypersensibilitate es producite in le duodeno. Hypersensibilitate alimentari a induction per parasitos ha non previemente essite reportate.
Article and Author Information
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From the Departments of Virus Diseases and Medical Zoology, Division of Communicable Disease and Immunology, Walter Reed Army Institute of Research, Washington, D. C.
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- Received June 26, 1964.
- Accepted August 11, 1964.
