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Acute Monarticular Arthritis After Vaccination
Report of a Case with Isolation of Vaccinia Virus from Synovial Fluid
- HOWARD M. SILBY, M.D.;
- ROGER FARBER, M.D.;
- CORNELIUS J. O'CONNELL, M.D.;
- JULIAN ASCHER, M.D.; and
- EDWARD J. MARINE, M.D.
- Requests for reprints should be addressed to Capt. E. J. Marine, USAF(MC), Department of Medicine, Davis-Monthan Air Force Base, Tucson, Ariz.
Excerpt
Arthritis has been described as an occasional complication of several viral diseases. However, to the authors' knowledge, the isolation of a specific virus from human synovial fluid in such cases has not been reported previously. The present report documents a case of acute monarticular arthritis after smallpox vaccination in which vaccinia virus was recovered from the synovial fluid.
CASE REPORT E. J. (BGH 293446), a 65-year-old Negro female, was admitted to the Buffalo General Hospital on June 25, 1963, because of fever and a painful swelling of the right knee. Twelve days previously, at her request, she had been vaccinated
Acknowledgment
The authors are indebted to Dr. Evan Calkins for critically reviewing the manuscript.
Summario in Interlingua
Es describite un caso de arthritis acute in le genu dextere, occurrente post vaccination routinari contra variola. Il pare que isto es le prime caso in que virus de vaccinia esseva identificate in le liquido synovial de un patiente human. Es postulate, como pathogenese possibile, que le viremia que cognoscitemente seque le vaccination pote resultar in focos metastatic. In le presente caso, le articulation del genu esserea le sito de un tal foco metastatic. Le autores opina que studios pro virus deberea esser interprendite in omne casos de arthritis in le quales le etiologia non es directemente apparente.
Article and Author Information
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From the Department of Medicine and the Department of Bacteriology and Immunology, State University of New York at Buffalo, and the Buffalo General Hospital, Buffalo, N. Y.
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- Received June 19, 1964.
- Accepted July 31, 1964.
