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Studies on the Pathogenesis of Rheumatoid Joint Inflammation
III. The Experimental Production of Arthritis by the Intra-articular Injection of Purified 7S Gamma Globulin
- RONALD A. RESTIFO, M.D.;
- ANDRE J. LUSSIER, M.D.;
- ARNOLD J. RAWSON, M.D.;
- JOHN H. ROCKEY, M.D.; and
- JOSEPH LEE HOLLANDER, M.D., F.A.C.P.
- Requests for reprints should be addressed to Joseph Lee Hollander, M.D., Hospital of the University of Pennsylvania, 34th and Spruce Sts., Philadelphia, Pa. 19104.
Excerpt
The finding of leukocytes containing cytoplasmic inclusion granules ("R.A. cells") in the synovial fluids of rheumatoid patients has stimulated an hypothesis for the pathogenesis of the inflammatory changes in this disease (1). This proposes that the inflamed joint results from the phagocytosis of intra-articular complexes of rheumatoid factor and 7S gamma globulin by leukocytes. Supporting such a concept are the release of rheumatoid factor from washed rheumatoid synovial fluid cells fractured by ultrasound (2), the demonstration of intracytoplasmic particulate 7S and 19S gamma globulin in rheumatoid synovial fluid leukocytes (3), and the in vitro phagocytosis of complexes of rheumatoid factor
This 100-word excerpt has been provided in the absence of an abstract.
Acknowledgment
We acknowledge with gratitude the clinical assistance of Dr. Ross Jeremy and the technical assistance of Miss Nina Shopa and Miss Barbara Yanowsky in the performance of this study.
Summario in Interlingua
In le prime communication de iste serie le hypothese esseva formulate que rheumatoide inflammation articular resulta ab le phagocytosis de complexos intra-articular de factor rheumatoide e globulina gamma 7S per leucocytos.
Pro testar iste hypothese, autologe globulina gamma 7S in forma purificate esseva injicite in le genus non-afficite de patientes rheumatoide qui cognoscitemente portava factor rheumatoide. Arthritis acute resultava in cinque inter sex casos. Le injection de purificate rheumatoide globulina gamma 7S in le genus de tres patientes con arthritis rheumatoide (homologe) e de cinque patientes con osteoarthritis produceva nulle reaction. Le injection intra-articular de non-rheumatoide globulina gamma 7S produceva inflammation articular in solmente un inter septe essayos in patientes rheumatoide.
Iste datos preliminari tende a corroborar le supra-mentionate hypothese. Illos permitte le speculation que un del passos in le pathogenese de inflammation rheumatoide es le alteration del molecula de globulina gamma 7S in un tal maniera que illo deveni specificamente antigenic.
Article and Author Information
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From the Arthritis Section, Department of Medicine, and the Department of Surgical Pathology, Hospital of the University of Pennsylvania, and the Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pa.
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- Received October 19, 1964.
- Accepted November 25, 1964.
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