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Cytogenetic Studies in Eosinophilic Leukemia
The Relationship of Eosinophilic Leukemia and Chronic Myelocytic Leukemia
- KONG-OO GOH, M.D.;
- SCOTT N. SWISHER, M.D.; and
- CHARLES A. ROSENBERG, M.D.
- Requests for reprints should be addressed to Kong-oo Goh, M.D., Cytogenetic Program, Medical Division, Oak Ridge Institute of Nuclear Studies, Oak Ridge, Tennessee 37831.
Excerpt
Frequently moderate degrees of hyper-eosinophilia have been found to be associated with many diseases (1). However, there are occasional cases in which the eosinophilia cannot be ascribed to a primary disease. Some of these cases are thought to be either myelocytic leukemia of eosinophilic variety or eosinophilic leukemia (2, 3).
In 1960, Nowell and Hungerford (4) described an abnormal small acrocentric chromosome in patients with chronic myelocytic leukemia. This abnormal chromosome has been called the Philadelphia chromosome or Ph1 (5). This abnormal chromosome has been thought to be typical of chronic myelocytic leukemia by many authors (6-9). Experience in this
Summario in Interlingua
Es reportate le resultatos de studios cytogenetic in duo patientes reguardate como exemplos de leucemia eosinophilic. Ben que le chromosoma Ph1, que es typic de chronic leucemia myelocytic, non esseva trovate in iste patientes, chromosomas a anormalitate morphologic esseva presente in ambes. Un multo grande chromosoma acrocentric esseva vidite in quatro metaphases in un cultura de leucocytos de sanguine peripheric ab un del patientes e in sex metaphases in un preparato directe de medulla ossee ab le altere. Nulle evidentia suggere que iste chromosoma anormal reimplaciava un particular chromosoma normal. Iste constatationes suggere que leucemia eosinophilic non es un variante de chronic leucemia myelocytic in que proliferation eosinophilic es plus prominente pro le un o le altere ration. Illos indica plus tosto que leucemia eosinophilic es un distincte maligne disordine myeloproliferative.
Article and Author Information
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From the Departments of Medicine and Obstetrics-Gynecology, University of Rochester School of Medicine and Dentistry, Rochester, New York, and the Department of Medicine, Veterans Administration Hospital, Batavia, N. Y.
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This study was supported in part by the Monroe County Cancer Association, a general research support grant (Fr-05103-01), U. S. Public Health Service, Bethesda, Md., and the Blood Research Fund of the University of Rochester, Rochester, N. Y.
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- Received July 1, 1964.
- Accepted July 31, 1964.
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