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Some Clinical, Biochemical, and Physiological Actions of the Pineal Gland
Combined Clinical Staff Conference at the National Institutes of Health
- ROBERT A. COHEN, M.D.;
- RICHARD J. WURTMAN, M.D.;
- JULIUS AXELROD, PH.D.; and
- SOLOMON H. SNYDER, M.D.
- Requests for reprints should be addressed to Robert A. Cohen, M.D., National Institute of Mental Health, Bldg. 10, Rm. 3-N-234, National Institutes of Health, Bethesda, Md. 20014.
Excerpt
Dr. Robert A. Cohen: On previous occasions when our Institute has had the responsibility for presenting one of these Combined Clinical Conferences I have considered it almost an obligation to choose for presentation those ongoing studies that are concerned at least in part with psychosocial aspects of behavior, since ours is the only program at NIH where the social and behavioral sciences are strongly represented. It is obvious, of course, that a fundamental understanding of behavior demands a theory that combines knowledge gained from such studies with that derived from a precise understanding of the biological processes and structures that
This 100-word excerpt has been provided in the absence of an abstract.
Summario in Interlingua
Tumores pineal pote esser associate con duo syndromes endocrin. (1) Destructive lesiones nonparenchymal que frequentemente produce un precoce pubertate in pueros e (2) ver tumores parenchymatose que es trovate in juvenes con retardate disveloppamento sexual. Patientes con cata-un del duo syndromes es describite.
Le corpore pineal contine un hormon, melatonina (5-methoxy-N-acetyltryptamina), le qual inhibi le crescentia ovarian e le incidentia del oestro in rattas. Il es solmente in le corpore pineal que le capacitate enzymatic ha essite demonstrate de synthetisar melatonina e altere methoxyindoles ab serotonina le qual illo contine in grande quantitates. Le activitate del enzyma que forma melatonina varia in le curso del die. Illo es le plus forte durante le nocte quando le rattas se trova in obscuritate. Illumination ambiental effectua un regulation del activitate de iste enzyma. Le lumine inhibi e le obscuritate stimula le synthese de melatonina. Information in re le illumination es transmittite al corpore pineal via un circuito neural in que le nervos sympathic participa. Viste que melatonina inhibi le crescentia ovarian e le incidentia de oestro vaginal in rattas e viste in plus que iste aspectos del function gonadal es ambes stimulate per illumination, il es postulate que le lumine exerce un parte de su effecto neuroendocrin per effectuar modificationes in le synthese de melatonina pineal.
Quando le nervos sympathic que duce al corpore pineal es destruite, tanto le corpore pineal como etiam le gonades perde lor capacitate de responder a lumine. Lumine augmenta le activitate del enzyma pineal le qual synthetisa serotonina etiam via un circuito neural.
Tissu tumoral ab un patiente con un metastatic pinealoma parenchymal esseva examinate, e le presentia in illo de serotonina, melatonina, e le enzyma que forma melatonina esseva constatate. Isto constitue le prime description de iste enzyma in tissu altere que illo del normal corpore pineal.
Article and Author Information
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This is an edited transcription of a combined clinical staff conference at the Clinical Center, Bethesda, Md., by the National Institute of Mental Health, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare.
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- Received September 4, 1964.
- Accepted September 17, 1964.
