Malignant Lymphoma in Survivors of the Atomic Bomb in Hiroshima

  1. ROBERT E. ANDERSON, M.D.; and
  2. KENZO ISHIDA, M.D.
  1. Requests for reprints should be addressed to Robert E. Anderson, M.D., Atomic Bomb Casualty Commission,
    Hijiyama Park, Hiroshima, Japan
    .

Excerpt

A causal relation between leukemia and ionizing radiation has been well documented in both man and laboratory animals (1-4). Similarly, there is an increased frequency of myelofibrosis with myeloid metaplasia in survivors of the atomic bomb in Hiroshima (5). Since a close relationship between the myeloproliferative disorders and malignant lymphomas is now generally accepted, the occurrence of the malignant lymphomas might be expected to be increased in survivors of the atomic bomb.

This report concerns the prevalence of Hodgkin's disease, lymphosarcoma, reticulum cell sarcoma, and multiple myeloma in the surgical and autopsy material examined at the Atomic Bomb Casualty Commission

Summario in Interlingua

Le presente studio demonstra un augmentate prevalentia de morbo de Hodgkin, lymphosarcoma, e myeloma multiple in proximalmente locate superviventes del bomba atomic in Hiroshima le quales esseva subjicite a examines chirurgic o necroptic in le installationes del Commission pro Victimas del Bomba Atomic (= Atomic Bomb Casualty Commission = ABCC). Le occurrentia de sarcoma de cellulas reticular pare esser reducite in le mesme gruppo de individuos. Le materiales pathologic que demonstra iste relationes consiste de 91 casos inequivoc de lymphoma maligne e es derivate ab duo essentialmente independente fontes del ABCC, le serie necroptic e le serie diagnostic de biopsias de nodos lymphatic. Le consideration del characteristicas epidemiologic de iste materiales supporta le notion que le mentionate augmento de prevalentia es un reflexion del occurrentia de lymphoma in le population general de individuos exponite intra le distantia de 1.400 m ab le hypocentro. In plus, proximalmente exponite subjectos tende a morir a plus juvene etates que distalmente exponite o non exponite subjectos. Le lymphomas examinate in exponite e non exponite individuos non differe morphologicamente intra le correspondente categorias diagnostic.

Article and Author Information

  • From the Department of Pathology, Atomic Bomb Casualty Commission, Hiroshima, Japan. (A research agency of the U. S. National Academy of Sciences-National Research Council under a grant from the U. S. Atomic Energy Commission administered in cooperation with the Japanese National Institute of Health of the Ministry of Health and Welfare.)

    • Received March 30, 1964.
    • Accepted June 26, 1964.
« Previous | Next Article »Table of Contents

This Article

  1. Ann Intern Med November 1, 1964 vol. 61 no. 5 Part 1 853-862
  1. » Excerpt
  2. Full Text (PDF)

Rapid Responses

  1. Submit a response
  2. No responses published

Current Issue

  1. November 17, 2009, 151 (10)
  1. Alert me to current issues