Pressor Activity of Renal Venous Blood in Hypertension

  1. JOHN J. MCPHAUL, JR.;
  2. DUNCAN A. MCINTOSH;
  3. LESTER F. WILLIAMS;
  4. EMIL J. GRITTI;
  5. WILLIAM G. MALETTE; and
  6. ARTHUR GROLLMAN, M.D., PH.D., F.A.C.P.
  1. CAPT. USAF (MC)
  2. CAPT. USAF (MC)
  3. CAPT. USAF (MC)
  4. MAJ. USAF (MC)
  5. MAJ. USAF (MC)
  1. Requests for reprints should be addressed to Arthur Grollman, M.D., The University of Texas Southwestern Medical School,
    5323 Harry Hines Blvd., Dallas, Texas 75235
    .

Excerpt

It is now well-established that the elevation in blood pressure of a small proportion of patients suffering from hypertensive cardiovascular disease is reversible and may be cured by partial or complete nephrectomy or by plastic repair of the renal artery (1-5). Despite the availability of such procedures as the differential analysis of the urine from each kidney, aortography, renal biopsy, etc., none of these have proven to be infallible in predicting which patients subjected to surgery will be benefited. As a consequence of this lack of a precise diagnostic criterion for the selection of patients, many are unnecessarily subjected to

Summario in Interlingua

Le non-tractate plasma del sanguine venose obtenite ab cata-un del renes de 56 patientes esseva essayate pro activitate pressori in le ratto. Le resultatos de iste essayage esseva correlationate con le constatationes clinic facite per altere disponibile procedimentos diagnostic e con le responsa del tension sanguinee a subsequente nephrectomia o reparo renovascular. Le datos assi establite indica que le methodo de essayage usate representa un accurate medio pro deteger patientes in qui chirurgia es promittente como tractamento de hypertension secundari a unilateral morbo renal e etiam pro predicer si nephrectomia o reparo renovascular va evocar un favorabile responsa. Le resultatos se trova de accordo con le opinion que le reversibile hypertension de patientes qui responde favorabilemente a nephrectomia o reparo renovascular es un responsa al elaboration, per le afficite ren, de un circulante agente pressori, per contrasto con le casos de patientes qui suffre de hypertension essential o de altere distincte formas de hypertension e in qui nulle agente pressori pote esser trovate.

Article and Author Information

  • From the Department of Medicine, Surgery, and Urology of the Wilford Hall USAF Hospital, Aerospace Medical Division (AFSC), Lackland Air Force Base, Texas, and the Department of Experimental Medicine, The University of Texas Southwestern Medical School, Dallas, Texas.

  • This investigation was supported in part by grant HE-07916 from the Heart Institute, National Institutes of Health, U. S. Public Health Service, Bethesda, Md.

    • Received March 19, 1964.
    • Accepted May 19, 1964.
« Previous | Next Article »Table of Contents