Hypogammaglobulinemia
Iodinated Gamma Globulin Studies
- ANANDA S. PRASAD, M.D., PH.D.;
- M. A. ABOUD, M.R.C.P., D.C.H.;
- A. SALAWI, M.D.; and
- ARTHUR R. SCHULERT, PH.D.
- Requests for reprints should be addressed to Ananda S. Prasad, M.D., Department of Medicine, Wayne State University College of Medicine, Detroit 7, Michigan.
Excerpt
Bruton first described primary agammaglobulinemia in male children in 1952 (1). Soon after, this condition was reported in adult females (2-5). This led to the recognition of two types of primary agammaglobulinemia: the congenital type seen in male children and an acquired variety occurring in adults of both sexes. Since then, approximately 200 cases of both kinds have been reported (6). Subsequently it has been shown that these patients have small quantities of gamma globulin in their plasma, and therefore the condition properly should be designated as hypogammaglobulinemia (7, 8). According to Good, Zak, Condie, and Bridges (8), the clinical
This 100-word excerpt has been provided in the absence of an abstract.
Acknowledgment
We wish to thank Dr. James H. Boyers, commanding officer, NAMRU-3, Cairo, Egypt, and Dr. William J. Darby, professor and chairman, Department of Biochemistry, Vanderbilt University, Nashville, Tennessee, for their help and support in this study.
We also wish to acknowledge gratefully the technical assistance of Adib S. Zeind and the support of Thomas Barnes.
Summario In Interlingua
In le curso de recente annos, duo typos de hypogammaglobulinemia primari ha essite recognoscite. Le un—le typo congenite—es incontrate in juveniles mascule, le altere—un varietate acquirite—occurre in adultos de ambe sexos. Un forma plus rar de hypogammaglobulinemia—probabilemente etiam congenite—esseva describite recentemente como occurrente in ambe sexos. Usualmente iste typo es minus complete, es associate con allargate nodos lymphatic e frequentemente con anemia hemolytic. Le presente communication describe un patiente con hypogammaglobulinemia qui pare representar le forma plus rar del typo congenite. Le metabolismo de globulina gamma marcate con I131 esseva studiate in iste patiente e comparate con duo subjectos de controlo. Le disparition de I131 ab le plasma e curvas de contation in vivo indicava que le patiente con hypogammaglobulinemia perdeva le radioactivitate plus lentemente que le subjectos normal. Le total excretion urinari de I131 e le velocitate del degradation de globulina gamma esseva plus basse in le patiente in comparation con le subjectos de controlo. Es concludite que le subjecto con hypogammaglobulinemia conservava globulina gamma in comparation con le normales.
Article and Author Information
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From the Medical Department of the U.S. Naval Medical Research Unit No. 3, Cairo, Egypt, U.A.R., the Division of Nutrition of the Departments of Medicine and Biochemistry, Vanderbilt University, Nashville, Tennessee, and the Pediatric Department, Faculty of Medicine, Cairo University, Cairo, Egypt, U.A.R.
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Supported by research contract Nonr-2149 from the Office of Naval Research and by a grant from the National Institutes of Health, United States Public Health Service, Bethesda, Maryland.
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The opinions and assertions contained in this paper are those of the authors and are not to be construed as official or reflecting the views of the Navy Department, the naval service at large, or the Egyptian Ministry of Public Health.
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- Received January 31, 1964.
- Accepted March 19, 1964.
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