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Chronic Medical Therapy for Pheochromocytoma
A Report of Four Cases
- KARL ENGELMAN, M.D.; and
- ALBERT SJOERDSMA, M.D., PH.D.
- Requests for reprints should be addressed to Albert Sjoerdsma, M.D., National Heart Institute, Bethesda, Maryland.
Excerpt
Since the first successful operation for pheochromocytoma in 1927 (1), the treatment of choice for this condition has been surgical excision of the tumor. Pharmacological therapy with phentolamine methanesulfonate (Regitine®, Ciba Pharmaceutical Products) or phenoxybenzamine (Dibenzyline®, Smith, Kline & French) to prepare the patient with a pheochromocytoma for surgery and the use of phentolamine to control the paroxysmal hypertensive crises encountered during surgery have gained wide acceptance. However, the use of these adrenolytic drugs in the chronic treatment of patients with resectable pheochromocytoma or with medical contra-indications to surgery has not been widely reported. The results of chronic therapy with
Summario in Interlingua
Quatro patientes con pheochromocytoma esseva tractate chronicamente con administrationes oral de phenoxybenzamina (hydrochloruro de Dibenzylina®; Smith, Kline and French). Duo pueras con maligne pheochromocytoma metastatic, qui habeva hypertension de grados impericulante lor vitas, esseva tractate ambes durante periodos de plus que un anno, e le mesmo es a dicer pro un femina de 70 annos de etate con un tumor presumitemente benigne que non poteva esser resectionate proque illa esseva constituite de maniera que le risco chirurgic debeva esser reguardate como gravissime. Un quarte patiente feminin con xanthinuria e cardiomyopathia, associate con sever congestive discompensation cardiac esseva tractate durante plus que sex menses in preparation pro un successose intervention chirurgic. In le duo patientes con morbo maligne e in le femina de etate avantiate, le therapia resultava in un normalisation virtual del stato clinic. In le quarte patiente, le therapia resultava in un marcate melioration del stato cardiovascular, con le consequentia que il deveniva possibile resectionar le tumor chirurgicamente. Inhibition del biosynthese metabolic del catecholaminas esseva essayate con un numero de pharmacos experimental, sed nulle successo esseva obtenite. Le possibile rolo futur de inhibitores metabolic es discutite. A iste tempore, phenoxybenzamina es le melior agente pro le perdurative therapia medical de pheochromocytoma.
Article and Author Information
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From the Experimental Therapeutics Branch, National Heart Institute, Bethesda, Maryland.
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- Received April 2, 1964.
- Accepted April 21, 1964.
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