RSS Feeds
Rheumatic Fever in Children and Adolescents
A Long-term Epidemiologic Study of Subsequent Prophylaxis, Streptococcal Infections, and Clinical Sequelae
VI. Clinical Features of Streptococcal Infections and Rheumatic Recurrences
- ALVAN R. FEINSTEIN, M.D.;
- MARIO SPAGNUOLO, M.D.;
- HARRISON F. WOOD, M.D.;
- ANGELO TARANTA, M.D.;
- ESTHER TURSKY, R.N.; and
- EDITH KLEINBERG, B.S.
- Requests for reprints should be addressed to Alvan R. Feinstein, M.D., Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven 11, Connecticut.
Excerpt
When a large group of children and adolescents is examined repetitively at monthly intervals after an attack of acute rheumatic fever, three main kinds of clinical events may be anticipated: [1] streptococcal infections, [2] recurrences of rheumatic fever, and [3] changes in cardiac status. A population of 431 young rheumatic patients, in whom these events could be observed, was originally assembled for long-term study of the antistreptococcal and antirheumatic effectiveness of three prophylactic regimens. The results of the prophylaxis study, and some selected correlations of the recurrent streptococcal and rheumatic inflammation, have been reported elsewhere (1-5).
Despite the continuous use
Article and Author Information
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From Irvington House, Irvington-on-Hudson, New York, and the Departments of Medicine and Pediatrics, New York University School of Medicine, New York.
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This work was supported in part by the National Heart Institute grant H-1595 (C-1-8), American Heart Association, New York Heart Association, Westchester Heart Association, and Wyeth Laboratories.
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Drs. Feinstein and Wood are currently with the Department of Internal Medicine and the Department of Pediatrics, respectively, Yale University School of Medicine, New Haven, Connecticut.
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- Received January 30, 1963.
- Accepted June 10, 1963.
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