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Respiratory and Cardiac Arrest After Intravenous Administration of Kanamycin with Reversal of Toxic Effects by Neostigmine
- CHARLES R. REAM, M.D.
- Requests for reprints should be addressed to Charles R. Ream, M.D., Physician in Chief, Saint Elizabeth Hospital, Elizabeth, New Jersey.
Excerpt
The purpose of this report is threefold: [1] to alert physicians to the curare-like effects that kanamycin may have on patients when it is administered intravenously; [2] to acquaint them with circumstances that may contribute to toxicity; and [3] to inform them as to the use of effective antidotes. Kanamycin is often used intravenously when a patient is critically ill with a serious infection. In such a patient kanamycin may, because of its generalized neuromuscular blockage, cause respiratory insufficiency and eventually respiratory arrest.
CASE REPORT This 16-year-old white female was admitted to Saint Elizabeth Hospital for the first time on
Summario in Interlingua
Es presentate un caso in que arresto respiratori e cardiac occurreva post le rapide administration intravenose de kanamycina. Iste adverse reaction respiratori ha previemente essite describite solmente post administrationes intraperitonee o intrapleural del pharmaco.
Gluconato de calcium se trova reportate in le litteratura como le agente de election in le effortio de reverter le mentionate adverse effectos de kanamycina, sed in le presente caso illo non se provava efficace del toto. Del altere latere, neostigmina esseva dramaticamente efficace in le reversion del bloco neuromuscular de apparentia curaroide.
Ben que ethere esseva implicate in omne le previemente reportate casos con un exception, illo non esseva presente in le caso hic reportate.
Article and Author Information
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From Saint Elizabeth Hospital, Elizabeth, New Jersey.
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- Received June 3, 1963.
- Accepted June 12, 1963.
