Neoplastic Plasma Cell
Combined Clinical Staff Conference at the National Institutes of Health
- NATHANIEL I. BERLIN, M.D.;
- RUTH MERWIN, PH.D.;
- MICHAEL POTTER, M.D.;
- JOHN L. FAHEY, M.D.;
- PAUL P. CARBONE, M.D.; and
- MARTIN J. CLINE, M.D.
- Requests for reprints should be addressed to Nathaniel I. Berlin, M.D., National Cancer Institute, Bethesda 14, Maryland.
Excerpt
Dr. Nathaniel I. Berlin: Multiple myeloma is a disease of the plasma cells, characterized by lytic lesions in the bone and by the production of abnormal proteins, for which there is no satisfactory therapy. New approaches utilizing advances in protein chemistry, immunology, and biology have made possible a number of studies of the malignant plasma cell in man and in mice. Plasma-cell tumors have been produced in mice—experimental animal tumors that are comparable to multiple myeloma in man.
In preparing this program I have selected from a larger number of studies in the National Cancer Institute those which illustrate selected
This 100-word excerpt has been provided in the absence of an abstract.
Summario in Interlingua
Le presente conferentia consisteva de 5 presentationes concernente le neoplastic Plasmazelle. Le presentationes discuteva le occurrentia de tumores a Plasmazellen in animales experimental e lor induction per varie methodos. Tumores a Plasmazellen ha essite inducite per le camera-filtro Millipore e per oleo mineral. Ha essite demonstrate que tal tumores produce un spectro de proteinas simile a illos que occurre in myeloma multiple. Iste tumores es transplantabile e mantene lor capacitate proteino-productori. In le forma ascitic iste tumores se ha provate utile in studiar le effecto de varie agentes chimotherapeutic. Esseva trovate que le anemia de myeloma multiple resulta in grande mesura ab le non-production de adequate numeros de erythrocytos in combination con un certe accurtamento del superviventia del erythrocytos. Amelioration del anemia esseva obtenite in 4 inter 5 patientes con androgenos in grande doses.
Article and Author Information
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This is an edited transcription of a combined clinical staff conference at the Clinical Center, Bethesda, Maryland, by the National Cancer Institute, National Institutes of Health, United States Public Health Service, Department of Health, Education, and Welfare.
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- Received March 6, 1963.
- Accepted March 22, 1963.
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