Human Gamma Globulin
Genetic Control and Its Relation to Disease
- HUGH FUDENBERG, M.D.; and
- E. C. FRANKLIN, M.D.
- Requests for reprints should be addressed to Hugh Fudenberg, M.D., Department of Medicine, University of California Medical Center, San Francisco, California.
Excerpt
The existence of genetically determined differences in certain serum proteins, comparable to genetic variations in blood type, eye color, and other hereditary traits, has become apparent in recent years. Evidence of such intraspecies heterogeneity was provided by the observations of Cumley and Irwin in 1942 (1) and confirmed by Thompson, Foster, Gowen, and Tauber in 1954 (2). In the past 5 years, hereditary differences in several groups of proteins in normal human serum have been definitely delineated. Different types of haptoglobin and of transferrin, for example, can be readily detected by dissimilarities in their electrophoretic behavior in starch gel (3-5).
This 100-word excerpt has been provided in the absence of an abstract.
Summario in Interlingua
Es revistate brevemente le relation inter le typos hereditari de globulina gamma e le subunitates structural de globulina gamma human. In globulina gamma 7S in humanos, serologicamente detegibile factores regulate per genes in 2 distincte locos es relationate con 2 distincte catenas con differente proprietates chimic, immunologic, e biologic. Super le base de un analogia con le hemoglobinas human, un hypothese es presentate concernente le presentia e le regulation genetic de altere distinctive catenas in le componentes gamma 1A e 19S. Es supponite que omne le 3 componentes del globulinas gamma—como le 3 componentes de normal hemoglobina adulte—consiste de 2 catenas, le un commun al 3 immuno-globulinas e le altere peculiar al specific immuno-globulina individual. Quatro locos genetic governa le elaboration del singule catena commun e del 3 catenas distinctive. Evidentia in supporto de iste hypothese es providite per observationes que suggere le occurrentia de un geneticamente determinate repression de un del subunitates structural in subjectos con varie formas de agammaglobulinemia. Es suggerite que aberrationes quantitative in un o un altere del varie catenas del globulinas gamma human es relationate a genes repressori in un o plures del postulate 4 locos e que le varie formas de agammaglobulinemia in humanos es determinate per le locos correspondente a mutante genes repressori.
Article and Author Information
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From the Departments of Medicine of the University of California School of Medicine, San Francisco, California, and the New York University School of Medicine, New York, New York.
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Supported by grants H-5997, A-2594, A-1431, and A-5141, United States Public Health Service, and by funds from the Northern California Chapter of the Arthritis and Rheumatism Foundation, and the Committee on Research, University of California School of Medicine, San Francisco.
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- Received May 28, 1962.
- Accepted September 12, 1962.
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