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The Metabolism of the Catecholamines (Clinical Implications)
Combined Clinical Staff Conference of the National Institutes of Health
- ROBERT A. COHEN, M.D.;
- WILLIAM F. BRIDGERS, M.D.;
- JULIUS AXELROD, PH.D.;
- HANS WEIL-MALHERBE, M.D.;
- ELWOOD H. LABROSSE, M.D.;
- WILLIAM E. BUNNEY, JR., M.D.;
- PHILIPPE V. CARDON, JR., M.D.; and
- SEYMOUR S. KETY, M.D.
- Requests for reprints should be addressed to Robert A. Cohen, M.D., National Institute of Mental Health, Bethesda 14, Maryland.
Excerpt
Dr. Robert A. Cohen: We wish to present today a review of some of our studies on the metabolism of the catecholamines. We shall begin with a discussion of some basic research on biosynthesis, and on the action of certain psychotropic drugs on the metabolism of the amines, and will then move on to clinical studies in normal controls and patients.
We have selected this topic for several reasons. The catecholamines are of great importance to all of us; they are being widely studied throughout the National Institutes of Health, and we believe that it might be interesting to you
Summario in Interlingua
Es presentate un revista de studios del metabolismo de catecholamina conducite per le Instituto National de Salute Mental. Reportos es facite in re [1] le biosynthese de norepinephrina, [2] le effecto de drogas psychotrope super le metabolismo de catecholamina, [3] alterationes in le concentration e distribution intracellular de catecholaminas cerebral, [4] le metabolismo de catecholaminas in subjectos normal e schizophrenic, [5] le excretion de epinephrina e norepinephrina sub conditiones de stress psychologie, e [6] le excretion urinari de acido 3-methoxy-4-hydroxy-mandelic in humanos.
Al nivello clinic le interesse del Instituto National de Salute Mental se concentra in explorar le relationes inter (1) le comportamento objective e le variationes subjective in le stato de humor del patiente e (2) le functionamento endocrin. Cognoscentias in iste area es obviemente significative pro un meliorate comprension del comportamento in statos de salute e de morbo e es un condition necessari pro le disveloppamento de un therapeutica rational. Iste presentationes suggere le amplitude del studios fundamental que es necessari como fundamento pro nostre comprension del phenomenos clinic. Dr. Weil-Malherbe-inter alteros-ha nettemente signalate le possibile existentia de un relation inter le nivellos sanguinee e urinari de catecholamina e le varie statos mental. Le identification de acido 3-methoxy-4-hydroxy-mandelic e de metanephrina como metabolitos principal de epinephrina ha portate nos plus proxime a un bon comprension del production endogene del hormon, e progresso ha essite reportate in le disveloppamento de proceduras pro le accurate mesuration de ille metabolitos de epinephrina. Si tosto que iste effortios ha completemente succedite, tal mesurationes pote esser combinate con cautemente determinate correlatos psychiatric e comportamental in le spero de attinger assi un meliorate definition del catecholaminas in le moduation e modification del affectos e del formas de comportamento.
Article and Author Information
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This is an edited transcription of a combined clinical staff conference at the Clinical Center, Bethesda, Maryland, by the National Institute of Mental Health, National Institutes of Health, Public Health Service, Department of Health, Education, and Welfare.
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- Received February 28, 1962.
- Accepted March 30, 1962.
