Aminoaciduria in an Elderly Man with the Nephrotic Syndrome and in a Young Man with a Variant of the Fanconi Syndrome

doi:10.1059/0003-4819-56-3-448

Aminoaciduria in an Elderly Man with the Nephrotic Syndrome and in a Young Man with a Variant of the Fanconi Syndrome

(MC), USN, F.A.C.P.

Requests for reprints should be addressed to the Director, Clinical Investigation Center, U. S. Naval Hospital,
Oakland 14, California
.

Excerpt

Normally, in a fasting human subject, almost all of the amino acids filtered at the glomerulus are reabsorbed (1). If the filtered load of an amino acid is increased, both the amount reabsorbed as well as that excreted are increased; indeed, in man no clear-cut maximal reabsorptive rate (Tm) has as yet been demonstrated for any amino acid (2). It follows that a major determinant of the amount of an amino acid excreted is the amount filtered, and justification can thus be made for defining an aminoaciduria in terms of the fraction of the filtered load which is excreted. In

Acknowledgment

The authors are greatly indebted to Dr. Fred R. Otten of La Grande, Oregon, for his generous cooperation in a number of matters relevant to the second patient (Case 2) in the present report.

Summario in Interlingua

Le amino-acidos e le alpha-ceto-acidos del plasma e del urina esseva studiate in duo patientes consignate al clinica renal del statounitese Hospital Naval Oakland in California. Le un veniva a causa del syndrome nephrotic, le altere a causa de persistente proteinuria.

Esseva trovate que ambes habeva generalisate aminoaciduria. In le homine de etate avantiate con le syndrome nephrotic, isto esseva accompaniate de glycosuria, dysfunction del mechanismo de acidification del urina, e un apparente alpha-ceto-aciduria. In le juvene homine, le amino-aciduria esseva accompaniate de uricosuria, creatinuria, e un basse concentration de phosphoro seral. Esseva trovate que le fratre de iste patiente habeva amino-aciduria e glycosuria. Ni le patiente ni su fratre evidentiava patente morbo ossee.

Le occurrentia de amino-aciduria in association con le syndrome nephrotic es sublineate de novo. Es opinate que le plus juvene del duo homines ha un variante del syndrome de Fanconi.

Article and Author Information

From the Clinical Investigation Center, U. S. Naval Hospital, Oakland, California.
Supported in part by Contract Nonr-222 (51) between the University of California, San Francisco, and the Office of Naval Research, Department of the Navy, Washington, D. C.
The opinions or assertions contained herein are the private ones of the authors, and are not to be construed as official or as necessarily reflecting the views of the Medical Department of the Navy or of the Naval Service at large.
- Received October 9, 1961.
- Accepted December 8, 1961.