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Primary Hyperoxaluria
- CAPT. ANGUS W. MCLAURIN;
- MAJOR WILLIAM R. BEISEL;
- GERALD J. MCCORMICK, M.S.;
- CAPT. RAYMOND SCALETTAR; and
- CAPT. ROBERT H. HERMAN
- Requests for reprints should be addressed to Capt. Angus W. McLaurin (MC) USAR, Department of Metabolism, Walter Reed Army Institute of Research, Washington 12, D. C.
Excerpt
Primary hyperoxaluria is characterized by an increased urinary excretion of oxalate and the deposition of calcium oxalate crystals in the kidneys and other organs. This metabolic defect was thought initially to be a severe disease of infancy and childhood, characterized by recurrent nephrolithiasis and pyelonephritis and by a progressive course terminating in a uremic death. Studies by Newns and Black (1) in 1953 and by Aponte and Fetter (2) in 1954 demonstrated an increased urinary excretion of oxalate prior to death in such patients. Subsequently, the disease has been diagnosed with increasing frequency during life, and others (3-7) have confirmed
Summario in Interlingua
Le constatation de elevate excretion urinari de oxalato esseva responsabile in quatro patientes pro le establimento de un diagnose de hyperoxaluria primari. Le forma plus tosto leve del morbo in iste patientes es characterisate per le formation e vacuation repetite de calculos renal e per le occurrentia de infection del vias urinari. Le elevation del oxalato urinari es le sol anormalitate laboratorial de nota. Per contrasto con lo que occurre in casos grave, nulle progressive disfallimento renal, nulle hypertension, e nulle uremia (con le normalmente associate disturbationes de crescentia e de nutrition) esseva constatate in le presente casos. Es discutite in detalio le relationes inter le varie circuitos de metabolismo intermediari que resulta in le formation de oxalato. Es presentate le conception que oxalato resulta como producto lateral in un cyclo que include acido glyoxylic, glycina, serina, e acido glycolic. Le therapia debe esser orientate verso le compensation e elimination (in tanto que possibile) del infection del vias urinari. Therapia a longe vista con pyridoxina non ha resultate in un significative reduction del excretion de oxalato, sed essayos con iste forma de therapia deberea esser continuate.
Article and Author Information
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Received for publication February 20, 1961.
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From the Department of Metabolism, Walter Reed Army Institute of Research, Washington 12, D. C.
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