Factors of Risk in the Development of Coronary Heart Disease—Six-Year Follow-up Experience

doi:10.1059/0003-4819-55-1-33

Factors of Risk in the Development of Coronary Heart Disease—Six-Year Follow-up Experience

The Framingham Study

WILLIAM B. KANNEL, M.D.;
THOMAS R. DAWBER, M.D., F.A.C.P.;
ABRAHAM KAGAN, M.D., F.A.C.P.;
NICHOLAS REVOTSKIE, M.D.; and
JOSEPH STOKES III, M.D.

Requests for reprints should be addressed to Thomas R. Dawber, M.D., F.A.C.P., Medical Director, Heart Disease Epidemiology Study,
25 Evergreen St., Framingham, Mass.

Excerpt

Increasingly reliable estimates of the prevalence and incidence of coronary heart disease (CHD) emphasize the importance of this disease as a contemporary health hazard. Cardiovascular disease is now the leading cause of death, with coronary heart disease accounting for two-thirds of all heart disease deaths. While advances in the diagnosis and therapeutic management of CHD have been made in the past decade, no important reduction in morbidity and mortality from CHD has occurred. This is apparent in the relatively slight increase in life expectancy at age 40 which has been achieved in the past several decades, while life expectancy at

This 100-word excerpt has been provided in the absence of an abstract.

Summario in Interlingua

Un specimen de 5.127 subjectos de etates de 30 a 59 annos, le quales initialmente esseva libere de morbo cardiac coronari, esseva observate durante sex annos. In le curso de iste intervallo, 125 masculos e 61 feminas disveloppava manifestationes de morbo cardiac coronari. Inter le 34 casos in le gruppo de etates ab 30 ad 44 annos, le proportion mascule a feminin de incidentia esseva 13 a 1. Inter le 152 casos in le gruppo de etates ab 45 ad 62 annos, le proportion mascule a feminin del incidentia esseva approximativemente 2 a 1. Le incidentia de angina de pectore esseva plus o minus equal pro le duo sexos. Tamen, infarcimento myocardial esseva duo vices plus commun in masculos e morte subite dece vices.

In masculos, un alte mortalitate immediate (30%) esseva associate con infarcimento myocardial initial (incluse mortes subite). Quarantacinque pro cento de 88 masculos suffrente infarcimento myocardial non esseva hospitalisate, primarimente a causa del facto que morte superveniva subitemente o que le infarcimento myocardial non esseva recognoscite como tal.

Factores de risco esseva evalutate in le gruppo de etates inter 40 e 59 annos. Hypertension (160/95 mm de Hg o plus) esseva associate con un quasi triplice augmento del risco in homines e un sextuple augmento in feminas. Elevation del nivello seral de cholesterol (245 mg per 100 ml o plus) esseva associate con un augmento plus que triplice del risco in masculos, durante que illo contribueva pauco (o nihil del toto) al augmento del risco in feminas. Le configuration electrocardiographic de hypertrophia sinistro-ventricular esseva associate con un augmento duplice o triplice del risco de un disveloppamento de morbo cardiac coronari.

Combinationes del tres characteristicas resultava in un augmento progressive in le risco de disveloppar morbo cardiac coronari, durante que subjectos libere de omne le mentionate anormalitates disveloppava le morbo a un prorata de solmente un medietate de illo del population total de iste studio. Le anormalitates occurreva in le population con un frequentia sufficientemente alte pro meritar nostre sollicitude.

Article and Author Information

Received for publication April 19, 1961.
From the Heart Disease Epidemiology Study, Framingham, Mass., and the National Heart Institute, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare, Washington, D. C.