THE DYSGAMMAGLOBULINEMIC SYNDROME*†
- WILLIAM J. HAMMACK, M.D.;
- F. ELNA BOLDING, B.S.; and
- WALTER B. FROMMEYER, JR., M.D., F.A.C.P.
- Requests for reprints should be addressed to Walter B. Frommeyer, Jr., M.D., Professor and Chairman, Department of Medicine, Medical College of Alabama, Birmingham, Alabama.
Excerpt
Plasma protein electrophoretic patterns revealing discrete and homogeneous globulin peaks have been interpreted to indicate either multiple myeloma, cryoglobulinemia or macroglobulinemia. The increased serum globulin found in cirrhosis, hyperglobulinemic purpura and hepatitis exhibits on paper electrophoresis diffuse and rounded peaks that are distinct from the discrete and homogeneous serum electrophoretic peaks found in the patients forming the basis of this report. Four male patients with discrete serum gamma globulin electrophoretic peaks have been observed for from two to three and one-half years without evidence of specific disease other than an inordinate susceptibility to infections. Although multiple myeloma may subsequently develop
This 100-word excerpt has been provided in the absence of an abstract.
Summario in Interlingua
Es presentate studios clinic e laboratorial effectuate in le casos de quatro patientes mascule. Tres habeva frequente pneumonias. In omnes, discrete piccos de globulina gamma esseva constatate in le electrophorese del sero. Studios ultracentrifugal non revelava macroglobulinemia, e tests pro cryoglobulinas e pyroglobulinas esseva negative. Studios immunologic per medio de technicas a diffusion de gel revelava que iste proteinas esseva simile a proteinas de "myeloma" in tres del patientes e a macroglobulinas in le quarte. Nulle indication clinic de myeloma o de anormalitates del medulla ossee esseva presente in ulle del patientes durante periodos de inter un e tres e medie annos de observation. Le nivellos de properdina obtenite durante un periodo sin infection esseva basse. Le responsa immunologic a stimulation antigenic esseva pauco bon. Ben que hyperglobulinemia esseva presente, le syndrome clinic de hypoglobulinemia occurreva. Le tractamento ha essite un continue observation con le administration de antibioticos quando indicate. Studios currentemente in progresso va monstrar si injectiones de globulina gamma provide un protection contra iste repetite infectiones.
Article and Author Information
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↵* Received for publication July 7, 1958.
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From the Department of Medicine, University of Alabama College of Medicine, and Veterans Administration Hospital, Birmingham, Alabama.
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↵† These studies were supported in part by Research Grant CY-3013 from the National Cancer Institute of the National Institutes of Health, Public Health Service.
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