MYOCARDIAL METABOLISM*†

doi:10.1059/0003-4819-49-5-1201

MYOCARDIAL METABOLISM*†

Requests for reprints should be addressed to Richard J. Bing, M.D., Professor of Medicine, Washington University Medical Service, Veterans Administration Hospital,
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.

Excerpt

For many years the study of cardiac metabolism has been of concern primarily to the physiologist working on the isolated heart and to the biochemist interested in the general aspects of intermediary metabolism.^{1, 2, 3, 4, 5, 6, 7} Recently, the subject has also come to the attention of the surgeon and of the internist.⁸ The former has had to concern himself with the oxygen consumption and the efficiency of the arrested heart during cardiac surgery, while the internist has begun to think about the heart muscle in its relation to congestive heart failure and coronary occlusion.^{9, 10} In addition,

This 100-word excerpt has been provided in the absence of an abstract.

Summario in Interlingua

Le studios reportate concerne le metabolismo del arrestate, del fibrillante, e del naturalmente perfundite corde canin e human. Le corde arrestate usa circa 25% del oxygeno usate per le corde naturalmente perfundite. Es a constatar nulle differentia inter le corde fibrillante, le corde arrestate, e le battente corde non-perfundite quanto al grado del utilisation de oxygeno. Le efficacia del corde es multo superior a lo que esseva previemente estimate. Le enzymas oxydative del corde possede un considerabile grado de resistentia contra le effectos de anoxia. Finalmente, glycolysis aerobie occurre in le musculo cardiac in le presentia de oxygeno, providite que isto es precedite per un periodo de anoxia myocardial.

Le resultatos de studios metabolic in le corde human a pulso normal indica que acidos grasse contribue plus al metabolismo de energia in le myocardio que non importa qual altere substrato. A parte le acidos grasse, le corde pote utilisar glucosa, pyruvato, lactato, cetones e amino-acidos.

Le grande aviditate del corde pro grassia es possibilemente de vaste signification, multo in ultra del importantia de acidos grasse como combustibile pro le production de energia per le corde.

Es discutite studios del metabolismo myocardial in varie morbos, incluse diabete, congestive insufficientia cardiac, infarcimento myocardial, e choc hemorrhagic.

Article and Author Information

From the Department of Medicine, Washington University School of Medicine, and the Washington University Medical Service, Veterans Administration Hospital, St. Louis, Missouri.
↵† Work supported by U. S. Public Health Service grant No. H-2678, The American Heart Association, The Life Insurance Medical Research Fund, and the Tobacco Industry Research Fund.