THE PROHYPERTENSIVE AND ANTIHYPERTENSIVE ACTIONS OF THE KIDNEY*
- E. BRAUN-MENÉDEZ, M.D., F.A.C.P. (Hon.)
- Requests for reprints should be addressed to E. Braun-Menéndez, M.D., Institute of Physiology, Faculty of Medical Sciences, University of Buenos Aires, Buenos Aires, Argentina.
Excerpt
The role of the kidney in experimental renal hypertension—and probably also in human renal hypertension—is twofold. On the one hand, it has a prohypertensive action mediated by the release into the blood of a pressor substance, renin, which, by acting on a serum α-globulin, produces "angiotensin," an octapeptide with potent vasoconstrictor and pressor actions.
On the other hand, the normal kidney tissue exerts some kind of antihypertensive action the exact nature of which is still unknown.
This dual and contrariwise role is not unique in the organism. For instance, the adrenal cortex secretes hormones which may have opposite actions on
This 100-word excerpt has been provided in the absence of an abstract.
Summario in Interlingua
Le rolo del ren in hypertension renal experimental—e probabilemente etiam in hypertension renal in humanos—es duple. De un latere, iste organo exerce un forte action prohypertensive, mediate per le liberation a in le sanguine de un substantia pressori. Del altere latere, le histos del ren normal exerce un certe genere de effecto antihypertensive, le natura del qual es ancora speculative.
Le effecto prohypertensive del ren resulta del liberation de renina. Isto affice le globulina sanguinee angiotensinogeno con le resultante formation de angiotensina. E angiotensina es un octapeptido con forte activitate vasoconstrictori. Augmentate quantitates de renina ha essite trovate in le sanguine in casos de hypertension acute, tanto experimental como etiam in humanos. In casos de hypertension chronic, le resultatos del investigationes ha remanite contradictori. Sed augmentate quantitates de angiotensina ha essite trovate in le sanguine de chronicamente hypertensive canes e de patientes con hypertension maligne.
Le action antihypertensive del ren es discutite ab le puncto de vista del hypothese a renotrophina. Secundo iste theoria, hypertension resulta quando le production de renotrophina excede le capacitate del ren de destruer, utilisar, o transformar lo. Il ha essite possibile monstrar que conditiones experimental que accelera le production de renotrophina o que reduce le massa functional del ren resulta in un augmento del pression sanguinee. Del altere latere, le pression sanguinee de animales con hypertension renal experimental es reducite o normalisate quando le intensitate del production de renotrophina es reducite o quando le massa functional del ren es augmentate.
Article and Author Information
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From the Institute of Physiology, Faculty of Medical Sciences, University of Buenos Aires.
- Copyright ©, 1958, by The American College of Physicians
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