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PENICILLIN-CARONAMIDE THERAPY OF ENTEROCOCCUS ENDOCARDITIS*
- RUSSELL P. HAGER, Ph.D., M.D.;
- EDWARD J. HEITZMAN, M.D.; and
- RAYMOND M. YOUNG, Ph.D.
Excerpt
Enterococcus endocarditis has been shown to be particularly resistant to treatment. Of the unsuccessfully treated cases of bacterial endocarditis, the most frequent resistant organisms have been noted to be enterococci.1 Clark, Bryner and Rantz2 have stated that enterococci always tolerate higher penicillin concentrations than other streptococci, and although most species of streptococci occurring in this type infection are inhibited by 0.1 unit of penicillin per ml. of culture medium, the enterococci require over 0.5 unit and occasionally up to 50 to 100 units, the majority being inhibited by between 5 and 10 units. In order to attain therapeutic blood concentrations,
Note in Proof
Note: As of December 29, 1950 the patient had remained well with no recurrence of the infection.
Article and Author Information
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↵* Received for publication January 4, 1949.
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From the Medical Service, Rhode Island Hospital, Providence, Rhode Island.
