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Missed Opportunities in the Trial on Proton-Pump Inhibitor Therapy in Bleeding Peptic Ulcers
- Hwai-Jeng Lin, MD; and
- Yao-Chun Hsu, MD, MSc
- From Changhua Christian Hospital, Changhua 500, Taiwan, and Lotung Poh-Ai Hospital, Ilan 265, Taiwan.
TO THE EDITOR:
We would like to comment on the article by Sung and colleagues (1), which reaffirmed the clinical effectiveness of infusional esomeprazole as an adjuvant pharmacotherapy for patients at high risk for bleeding peptic ulcers. First, it is extraordinary that the rebleeding and mortality rates in the placebo recipients were 13.6% and 2.1%, respectively, which are noticeably lower than those in most previous reports. A recent Cochrane meta-analysis (2) revealed a rebleeding rate of 19.2% and a mortality rate of 4.9% in the patients with bleeding ulcers who …
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