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Vitamin K to Correct Overanticoagulation
- Mark A. Crowther, MD, MSc; and
- David Garcia, MD
- From McMaster University, Hamilton, Ontario L8N 4A6, Canada, and University of New Mexico, Albuquerque, NM 87131.
IN RESPONSE:
Our study found that low-dose oral vitamin K does not reduce bleeding in asymptomatic patients who present with INR values between 4.5 and 10.0. Thus, one should not recommend vitamin K to patients similar to those we enrolled if the intent is to reduce bleeding.
The INR decreased more rapidly in patients who received vitamin K, consistent with the pattern we have observed in previous studies. This INR decrease confirms that the formulation used in our study was effective (1). Similarly, we decided …
